2018年9月3日 · We compared the overall gene expression profile of poorly-differentiated (HLE, HLF, SNU-449) to well-differentiated (HUH7, HEPG2, HEP3B) HCC cell lines in three publicly available microarray datasets.

Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response.

肝细胞癌（hepatocellularcarcinoma，HCC）是近年来发病率急剧上升的恶性肿瘤之一。 肝癌细胞系广泛应用于各类肝癌的研究。 肝癌细胞系的基因组与健康人细胞系的基因组不同。

2018年5月3日 · Our research revealed that HCC-derived exosomes could mediate EMT and enhance malignancy of HCC cells, suggesting that they may be novel diagnostic markers and targets for prevention of...

2022年11月24日 · Enhanced activation of the transcription factor MYC and of the receptor tyrosine kinase MET are among the events frequently occurring in hepatocellular carcinoma (HCC). Both genes individually...

2018年3月7日 · Galunisertib modulated the expression of stemness-related genes only in the invasive (HLE and HLF) HCC cells inducing a decreased expression of CD44 and THY1. Furthermore, galunisertib also...

2018年9月5日 · 代谢组学研究表明，hle细胞的基因组画像与谷氨酰胺的高度依赖共存以促进三羧酸循环，而huh7细胞同时使用葡萄糖和谷氨酰胺。靶向谷氨酰胺途径选择性抑制hle细胞的增殖。 "点击查看英文标题和摘要"

Results: The differential expression of cell cycle/growth regulator in hepatocellular carcinoma (HCC) showed a stronger tendency toward cell proliferation with more than 1.5-fold up-regulation of Cyclin C, ERK5, ERK6, E2F-3, TFDP-2 and CK4. The anti-apoptotic factors such as Akt-1 were up-regulated, whereas the promotive genes of apoptosis such ...

2018年9月3日 · Metabolomics revealed that the genomic portrait of HLE cells co-exist with profound reliance on glutamine to fuel tricarboxylic acid cycle, whereas HUH7 cells use both glucose and glutamine. Targeting glutamine pathway selectively suppressed the proliferation of …

Objectives: Hepatocellular carcinoma (HCC) and cholangiolar carcinoma (CC) cell lines are used to analyze the basic mechanisms of carcinogenesis and target therapies. However, it is not yet clear which chromosomal aberrations are to be typically expected in such cell lines.