Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as “Shuizhi” in traditional Chinese medicine), is the strongest natural specific inhibitor of …

Hirudin is a single-chain 65-amino acid polypeptide (7,000 Da) that forms an irreversible 1:1 complex with thrombin. Hirudin interacts with both the fibrinogen-binding and catalytic sites of …

Hirudin is the most potent and specific known inhibitor of thrombin, the enzyme that plays a key regulatory function in hemostasis and blood coagulation.

The anticoagulant hirudin, which is extracted from the body tissues of the European medicinal leech (Hirudo medicinalis), is used to prevent blood clots following surgery; another chemical …

Over a century has passed since the anticoagulant properties of hirudin were identified. Our understanding of this unique and promising 65 amino acid polypeptide has grown steadily, …

2001年3月13日 · Hirudin was used for the first parenteral anticoagulation in humans in 1909 1 and as the anticoagulant for the first hemodialysis in humans. 2 Soon after, heparin became …

hirudin A substance secreted by the salivary glands of leeches to prevent blood coagulation so that they can continue to feed on blood. The leeches are, of course, unaware that their hirudin …

Hirudin forms a biomolecular complex with thrombin via its acidic C-terminus and thereby prevents the activity of thrombin. Hirudin has been produced synthetically and used in the …

2021年4月15日 · Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as “Shuizhi” in traditional Chinese medicine), is the strongest natural …

1995年7月1日 · Natural hirudin produced in the salivary glands of medicinal leeches is the most potent, selective, and specific inhibitor of thrombin.