High-risk multiple myeloma: how to treat at diagnosis and relapse?
2021年12月10日 · Identify high-risk myeloma based on patient-, disease-, or outcome-based factors. Be able to define the key objectives to overcome poor prognosis with the presence of high-risk features. Define the best therapeutic strategy for patients with high-risk features
High-Risk Multiple Myeloma Treatment - WebMD
2023年1月20日 · What Is High-Risk Multiple Myeloma? How Is High-Risk Multiple Myeloma Treated? Is a Stem Cell Transplant the Best Option for High-Risk Multiple Myeloma?
How I treat high-risk multiple myeloma | Blood | American …
2022年5月12日 · Survival of multiple myeloma (MM) has significantly improved over the past decade; however, a composed group of patients (15% to 20%), named high-risk (HR) MM, still experiences reduced survival.
Multiple myeloma with high-risk cytogenetics and its treatment …
Co-existing high-risk CAs (HRCAs) tend to be associated with an even worse prognosis. Achievement of sustained minimal residual disease (MRD)-negativity has recently emerged as a surrogate for longer survival, regardless of cytogenetic risk.
How to Treat High-Risk Myeloma at Diagnosis and Relapse
2021年5月19日 · High-risk multiple myeloma remains a challenge to diagnose and to treat. It is necessary to develop tools to readily identify patients with high-risk disease and to provide them with the most effective treatments available.
Multiple Myeloma: 2022 update on Diagnosis, Risk-stratification …
In high-risk patients, daratumumab, bortezomib, lenalidomide, dexamethasone (Dara-VRd) is an alternative to VRd. Selected standard risk patients can collect stem cells, get additional cycles of induction therapy, and delay transplant until first relapse.
Navigating High-Risk and Ultrahigh-Risk Multiple Myeloma: …
2024年5月21日 · Multihit myeloma (the co-occurrence of two or more high-risk cytogenetic abnormalities), extramedullary disease, plasma cell leukemia, and a high-risk gene expression profiling signature have emerged as defining features of ultrahigh-risk …
High-Risk Multiple Myeloma: Definition & Treatment - HealthTree
2024年7月8日 · What is High-Risk Myeloma? Dr. Dima explains that high-risk myeloma represents 15-20% of all multiple myeloma patients and is defined by specific genetic abnormalities and other factors. These factors indicate that the myeloma is more aggressive and likely to relapse sooner. For example:
High-Risk Myeloma: Definitions and Treatments
2024年6月27日 · A practical guide to defining high-risk myeloma for clinical trials, patient counseling and choice of therapy. Leukemia, 21(3), 529–534. DOI: https://doi.org/10.1038/sj.leu.2404516
How I Treat In Brief: Treatment of High-Risk Multiple Myeloma
Elena Zamagni, MD, Simona Barbato, PhD, and Michele Cavo, MD, review current definitions of high-risk multiple myeloma, the results of available trials with high-risk patients, and how to use risk-adapted treatment strategies in difficult-to-treat patients.
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