2018年1月17日 · We show that HIF-1α transcriptionally enhances Il10 mRNA expression. In line with our results, it has been shown that both IL-21 and IL-27 induce ERK and STAT3 activation and upregulate IL-10 in...

2023年7月5日 · For this purpose, we injected an mRNA that encodes a dominant active (DA) form of hif1αb bearing mutations at two prolines and one asparagine (P402A, P564G, N804A), hence preventing their ...

为了支持 hif-1α 在限制 xbp1 激活中发挥作用的假设，作者检测到 eae 期间 hif-1α 缺陷的脾 dc 中 xbp1 mrna 剪接增加（图 3f），并且 xbp1 向促炎细胞因子启动子的募集减少 用 ml228 稳定 hif-1α 后。

Here, we report that the hypoxic tumor microenvironment potently promotes ferroptosis resistance in solid tumors in a hypoxia-inducible factor 1α (HIF-1α)-dependent manner. In combination with HIF-2α, which promotes tumor ferroptosis under hypoxia, HIF-1α is the main driver of hypoxia-induced ferroptosis resistance.

2022年12月8日 · Here we demonstrate that the HIF-1 to HIF-2 transition during prolonged hypoxia is mediated by two mechanisms: (1) the HIF-1 driven increase in the glycolytic pathways that reactivates PHD activity and (2) the much less stable mRNA levels of HIF-1α (HIF1A) compared to HIF-2α (EPAS1) mRNA.

2022年6月20日 · Activation of HIF induces various effector pathways that mitigate the effects of hypoxia, including metabolic reprogramming and the production of erythropoietin. Drugs that target the HIF pathway...

2024年10月4日 · This study reviewed reports of laboratory exposures of adult ray-finned fishes to hypoxia and used generalized linear mixed effects models to examine the influence of HIFA gene, tissue sampled, and exposure conditions in explaining the diversity of responses seen in HIFA mRNA abundance.

studies indicate that HIFA mRNA abundance increases in tissues of fishes exposed to hypoxia. This study reviewed reports of laboratory exposures of adult ray-finned fishes to hypoxia and used generalized linear mixed effects models to examine the influence of HIFA gene, tissue sampled, and exposure

2015年9月1日 · HIF-1α inhibition can usually be achieved through modulation of one of the following steps: HIF-1α mRNA expression; HIF-1α protein level (protein translation or degradation); HIF-1α/HIF-1β dimerization; HIF-1α-DNA binding (HIF-1α/HRE); or HIF-1α transcriptional activity (CH-1 of p300/ C-TAD of HIF-1α).

2022年7月22日 · In this study, our data suggest that the mRNA expression level of HIF1α was higher in organs such as the brain tumors, gastrointestinal tumors (esophagus, pancreas, stomach, and gallbladder), and lung tumors compared with normal tissues, both at the tissue level and the cell line level.