036603 (CByB6F1/J x C3D2F1/J)/J HET3 (also called UM-HET3) mice are an established genetic diversity model for aging intervention studies, currently used by the NIA's Intervention Testing Program (ITP).

如果把这一长串字符解构一下，常见的基因工程小鼠可以分为两种命名方式： 基因定点修饰 的小鼠命名。 比如：敲除、敲入、点突变等等。 随机转基因 的小鼠命名。 基因定点修饰小鼠的命名. 这一类小鼠的名称基本长这样，下面我们对这些组成部分逐一说明： ★ 品系背景. 如果是在单一的小鼠背景上完成的基因修饰，并且在繁育过程中未引入其它品系，那么就可以以品系简写来表示。 比如： 如果是在混合品系背景上，那么可以用这几个品系（<3 个）缩写，并以分号作为间隔 …

2023年6月14日 · The genetically heterogeneous HET3 (UM-HET3) mice provide a unique, translatable platform for modeling human diversity in aging and for assessing therapies to prolong health.

2023年12月8日 · HET3 mice (also called UM-HET3) are a well-established, genetically heterogeneous mouse model used by the NIA’s Interventions Testing Program to reduce strain-specific characteristics on outcomes.

2017年11月14日 · Here we report that Mef2c +/− (Mef2c -het) mice exhibit behavioral deficits resembling those of human patients. Gene expression analyses on brains from these mice show changes in genes...

When collecting heterozygous mice from het X het crosses the parental origin of the mutation is unknown and cannot be controlled. By crossing het X wt, the parental origin of the mutation is controlled. Generate equal numbers of mutant experimental mice and control wild-type mice, controlling for the sex of the mouse.

Head tilt (het) is a recessive mutation in mice causing vestibular dysfunction. Homozygotes display abnormal responses to position change and linear acceleration and cannot swim. However, they are not deaf. het was mapped to the proximal region of mouse chromosome 17, near the T locus.

We assessed aging hallmarks in skin, muscle, and adipose in the genetically diverse HET3 mouse, and generated a broad dataset comparing these to individual animal diagnostic SNPs from the 4 founding inbred strains of the HET3 line. For middle- and old-aged HET3 mice, we provided running wheel exerci …

Head tilt (het) is a recessive mutation in mice causing vestibular dysfunction. Homozygotes display abnormal responses to position change and linear acceleration and cannot swim. However, they are not deaf. het was mapped to the proximal region of mouse chromosome 17, near the T locus. Here we repor …

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The mutation in the het mouse was identified as retroviral insertion into …