2025年1月9日 · A gene called HFE is most often the cause of hereditary hemochromatosis. You inherit one HFE gene from each of your parents. The HFE gene has two common mutations, C282Y and H63D.

2024年5月15日 · Hereditary hemochromatosis is most commonly caused by certain changes in a specific gene, called the HFE gene. If you inherit two of these genetic changes (mutations), one from each parent, you have hereditary hemochromatosis and are …

In the hereditary hemochromatosis (HH or HHC), males are usually diagnosed after their forties and fifties, and women some decades later, during menopause. The severity of clinical disease varies considerably.

Hereditary hemochromatosis is an autosomal recessive disorder that disrupts iron homeostasis, resulting in systemic iron overload. It is the most common inherited disorder...

2024年12月23日 · Hereditary hemochromatosis is a genetic condition that causes the body to absorb too much iron from food. This can lead to symptoms such as tiredness, weakness, joint...

Hereditary hemochromatosis is a genetic disorder characterized by excessive iron (Fe) accumulation that results in tissue damage. Manifestations can include systemic symptoms, liver disorders, cardiomyopathy, diabetes, erectile dysfunction, and arthropathy.

Hereditary hemochromatosis (HH) is the most common form of iron overload syndromes, i.e. diseases in which too much iron builds up in one’s body. This extra iron is toxic to the body and can damage organs, lead to illness or even death.

2024年9月5日 · The term “hemochromatosis” is generally used for iron overload due to a genetic cause. In most cases, an altered gene is inherited from both parents. A gene called HFE is most often involved (the "H" stands for hereditary or high; "Fe" is the chemical symbol for iron).

Hereditary hemochromatosis is an inherited disorder that increases the amount of iron that the body absorbs from the gut. Symptoms are caused by this excess iron being deposited in multiple organs of the body.

Type 4 hereditary hemochromatosis occurs largely in people of southern European ancestry. It results from an autosomal dominant mutation in the SLC40A1 gene and affects the ability of ferroportin, an iron-transport protein, to bind hepcidin. In type 4A disease, hepcidin production is normal but the export function of ferroportin is reduced, leading to intracellular iron retention …