GSDME maintains hematopoietic stem cells by balancing pyroptosis …
2020年12月8日 · Here, we show that hematopoietic stem and progenitor cells are capable to undergo pyroptosis in response to cisplatin treatment and GSDME is one of the genes mediating such process. Gsdme−/− mice revealed no difference in the steady state of blood system while Gsdme−/− HSCs exhibited compromised reconstitution capacity due to increased apoptosis.
NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic ...
2012年12月14日 · Unrestrained pyroptosis in hematopoietic stem and progenitor cells leads to leukopenia at steady state and to anemia and leukopenia during periods of hematopoietic stress induced by chemotherapy or infection. Pyroptosis is reported to be an effective mechanism of clearance for intracellular bacteria.
GSDMD is dispensable for hematopoietic homeostasis and hematopoietic …
2022年8月1日 · Several studies reported that Caspase-4/5/11 in the cytoplasm can be used as a sensor to directly bind to the surface LPS of gram-negative bacteria, and mediate the nonclassical pathway of cell pyrolysis and GSDMD is one of the key executive molecules mediating pyrolysis [8].
IRF1 regulates self-renewal and stress responsiveness to ... - Science
2023年10月27日 · Hematopoietic stem cells (HSCs) are tightly controlled to maintain a balance between blood cell production and self-renewal. While inflammation-related signaling is a critical regulator of HSC activity, the underlying mechanisms and the precise functions of specific factors under steady-state and stress conditions remain incompletely understood.
Inflammation’s Epigenetic Footprint in Hematopoietic Stem Cells
2020年5月7日 · In this issue of Cell Stem Cell, de Laval et al. (2020) describe persistent epigenetic modifications in hematopoietic stem cells following an inflammatory insult with LPS as a mechanism by which immune memory may be established. Higher organisms are constantly interacting with a range of bacteria and viruses.
ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM ...
2021年1月4日 · Pyroptosis is an inflammatory form of cell death that occurs in response to pathogenic infection and is typically driven by caspase-1 (CASP1) and/or caspase-11 (CASP11)-mediated cleavage of...
Induction of ASC pyroptosis requires gasdermin D or caspase …
2020年6月18日 · Here, we found that LPS, flagellin, dsDNA, nigericin (NIG), or LPS combined with nigericin (LPS/NIG) could not induce pyroptosis in adipose-tissue-derived mesenchymal stem cells (ASCs).
The Nox2-ROS-Nlrp3 Inflammasome Signaling Stimulates in the
2022年11月28日 · Proliferation, metabolism, and migration of hematopoietic stem/progenitor cells (HSPCs) are coordinated by receptors expressed on outer cell membranes that are integrated into microdomains, known as membrane lipid rafts (MLRs).
Lethal and sublethal effects of programmed cell death pathways …
Multiple cell death pathways are programmed in hematopoietic stem cells (HSCs). HSCs are protected by unique prosurvival mechanisms from their unnecessary loss through apoptosis. HSCs are vulnerable to certain types of programmed necrosis. Activation of programmed cell death pathways can affect HSC function without causing cell death.
Identification of immune-activated hematopoietic stem cells
2018年7月24日 · Hematopoietic stem cells (HSCs) are the source of both normal blood cells and leukemia [1]. The ability to identify and purify them using multiple surface markers, such as Lineage - cKit +...