Hematopoietic stem cell - Wikipedia
Hematopoietic stem cells are essential to haematopoiesis, the formation of the cells within blood. Hematopoietic stem cells can replenish all blood cell types (i.e., are multipotent) and self-renew. A small number of hematopoietic stem cells can expand to generate a very large number of daughter hematopoietic stem cells.
Haematopoietic stem cells: past, present and future
2017年2月6日 · Haematopoietic stem cells (HSC) are the architects of definitive haematopoiesis, that is, blood cell production that occurs continuously during the life of an organism.
Haematopoietic stem cells: past, present and future - PMC
The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis. Blood 2016; 128: 2285–2296. [Google Scholar] Sawai CM, Babovic S, Upadhaya S, Knapp DJ, Lavin Y, Lau CM et al. Hematopoietic stem cells are the major source of multilineage hematopoiesis in adult animals. Immunity 2016; 45: 597 ...
Hematopoietic stem cells: concepts, definitions, and the new reality
Hematopoietic stem cell (HSC) research took hold in the 1950s with the demonstration that intravenously injected bone marrow cells can rescue irradiated mice from lethality by reestablishing blood cell production. Attempts to quantify the cells ...
Hematopoietic Stem Cells - PMC - PubMed Central (PMC)
Hematopoietic stem cells (HSCs) are multipotent precursors that have self-renewal capacity and the ability to regenerate all of the different cell types that comprise the blood-forming system (Bonnet, 2002; McCulloch and Till, 2005).
Development of the hematopoietic system: expanding the ... - Cell …
2023年7月20日 · Hematopoietic stem cells (HSCs) give rise to nearly all blood cell types and play a central role in blood cell production in adulthood. For many years it was assumed that these roles were similarly responsible for driving the formation of the hematopoietic system during the embryonic period.
The genesis of human hematopoietic stem cells | Blood
2023年8月10日 · Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic waves that generate the differentiated blood cells required for embryonic development while establishing a pool of undifferentiated hematopoietic stem cells (HSCs) for …
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology - Cell …
2008年2月22日 · Hematopoietic stem cells (HSCs) reside as rare cells in the bone marrow in adult mammals and sit atop a hierarchy of progenitors that become progressively restricted to several or single lineages (Orkin, 2000).
Hematopoiesis: A Human Perspective: Cell Stem Cell - Cell Press
We highlight 2 decades of studies focusing on isolation and molecular regulation of human HSCs, therapeutic applications, and early lineage commitment steps, and compare mouse and humanized models to identify both conserved and species-specific mechanisms that will aid future preclinical research.
Introduction to a review series on hematopoietic stem cells
2023年8月10日 · Hematopoietic stem cells (HSCs) are responsible for the lifelong production of all blood lineages; therefore, their specification and maintenance are tightly regulated.