The leucocyte common antigen, protein tyrosine phosphatase receptor type C (PTPRC), also known as CD45, is a transmembrane glycoprotein, expressed on almost all haematopoietic cells except for mature erythrocytes, and is an essential regulator of T ...

2024年3月1日 · CD45——蛋白酪氨酸磷酸酶受体C (PTPRC)，又被称为白细胞共同抗原（LCA)，是一种1型跨膜蛋白酪氨酸磷酸酶 (PTPase)，在除成熟红细胞和血小板外的所有造血干细胞谱系细胞中均有表达，是T和B细胞抗原受体介导的活化的重要调节因子。

2023年9月20日 · 2023年8月31日，宾夕法尼亚大学Saar Gill 教授、Carl June 教授研究团队在Science 子刊 Science Translational Medicine 上发表了题为Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy 的研究论文，该论文介绍了一种血液肿瘤治疗的新思路。 论文研究团队通过靶向泛造血干细胞谱系表达的CD45蛋白，尝试开发一种“血液肿瘤通用”的 CAR-T细胞疗法。

2018年4月1日 · CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a certain cell type and the developmental or activation status of the cell.

The leucocyte common antigen (CD45) is an abundant glycoprotein expressed exclusively on the surface of all leucocytes and their progenitors. 1 CD45 expression appears at one of the earliest stages of haematopoietic development, suggesting that it plays a central role in the generation of a functional immune system.

CD45 is a transmembrane glycoprotein and protein tyrosine phosphatase expressed on the surface of all nucleated hematopoietic cells. While there is increasing evidence demonstrating the involvement of CD45 in immune system regulation, no information on CD45 expression in inflammation and sepsis is currently available.

The extracellular domain of CD45 is highly polymorphic in all vertebrates. Importantly, human polymorphic variants that alter CD45 isoform expression are associated with autoimmune and infectious diseases, establishing CD45 as an important immunomodulator with a significant influence on disease burden.

CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a certain cell type and …

2001年5月1日 · Identified as the first and prototypic transmembrane protein tyrosine phosphatase (PTPase), CD45 has been extensively studied for over two decades and is thought to be important for positively...

Here we report that the protein tyrosine phosphatase CD45 is an ideal candidate gene on which to base a hematopoietic reporter. CD45 regulatory elements were discovered by analyzing transcription factor chromatin occupancy (ChIP-seq) and promoter nuclease sensitivity (DNase-seq) to identify minimally sufficient sequences required for expression.