Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 (TIM-3) gene. HAVCR2 was first described in 2002 as a cell surface molecule expressed on IFNγ producing CD4+ Th1 and CD8+ Tc1 cells.

Mar 30, 2025 · HAVCR2 (Hepatitis A Virus Cellular Receptor 2) is a Protein Coding gene. Diseases associated with HAVCR2 include T-Cell Lymphoma, Subcutaneous Panniculitis-Like and Hepatitis A . Among its related pathways are Cytokine Signaling in Immune system and Interleukin-2 family signaling .

tim-3（t细胞免疫球蛋白粘蛋白-3，又称 cd366 、havcr2）是一种 负调控的免疫检查点蛋白 。 表达于CD4+T细胞亚群（Th1/Th17细胞）调节性T细胞(Tregs)、 CD8+T细胞 亚群(Tc1)以及天然免疫细胞（DC、NK 细胞、单核细胞和巨噬细胞）

Nov 2, 2020 · Most of the attention devoted to T-cell immunoglobulin and mucin domain-3 (TIM3; also known as HAVCR2 or CD366) molecules stems from their expression on exhausted T cells in settings of chronic...

tim3（t细胞免疫球蛋白及粘蛋白结构域分子3）又称havcr2，属于免疫调节蛋白tim家族的一员，在人类，tim家族包括tim1、tim3和tim4，位于染色体5q33.2上。 在小鼠中，TIM家族包括TIM1到TIM8，位于染色体11B1.1上。

Mar 8, 2025 · Hepatitis A virus cellular receptor 2 (HAVCR2) is decreased with viral infection and regulates pro-labour mediators OA. Liong S, et al. Am J Reprod Immunol, 2017 Jul. PMID 28466996. Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity.

该蛋白是一种 Th1 特异性细胞表面蛋白，可调节巨噬细胞活化，抑制 Th1 介导的自身免疫和同种免疫反应，并促进免疫耐受。 [RefSeq 提供，2011 年 9 月] The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on …

HAVCR2在自身免疫性疾病、感染性疾病、肿瘤免疫监视和免疫逃逸等免疫反应的调节中发挥着不同的作用，是适应性免疫中的一种抑制分子，且在某些肿瘤中表达水平的变化与疾病进展相关，因此它也是免疫治疗研究中的潜在靶点。 (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. Immunofluorescence staining of Hela cell with CSB-RA010145MA1HU at 1:150, counter-stained with DAPI.

石蜡包裹的人肺癌组织中HAVCR2的免疫组织化学分析。 HAVCR2表达在肺，胃，头颈癌， schwannoma ，Schwannoma，黑色素瘤和卵泡B细胞非霍奇金淋巴瘤中的肿瘤浸润淋巴细胞中受到调节。 HAVCR2途径可能与功能失调的CD8 + T细胞中的PD-1途径与癌症中的Treg相互作用。

Apr 23, 2019 · The HAVCR2 gene encodes a critical negative regulator in the immune system, acting as a negative checkpoint in peripheral tolerance and innate immune and inflammatory responses (summary by Gayden et al., 2018). CD4 -positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 ...