Applied during endoscopy to bleeding lesions, TC-325 is derived from bentonite, and is used to achieve hemostasis (control of bleeding) by absorbing water and creating a barrier that leads to mechanical tamponade (pressure) and concentration of clotting factors, resulting in enhanced coagulation (clotting of blood). [1] .

The use of a novel hemostatic powder spray appears to be effective and safe in controlling upper and lower gastrointestinal bleeding. Although initial reports of hemostatic powder spray as an innovative approach to manage gastrointestinal bleeding are promising, further studies are needed to support and confirm its efficacy and safety.

Used for hemostasis of nonvariceal gastrointestinal bleeding. The products on this website are available for sale in the United States. Reference Part Numbers are not the same in all countries/regions.

2013年1月4日 · Application of hemostatic granules and powders can control bleeding in animal arterial bleeding models and has been used for treatment of combat injuries. 1,2 Use of such a hemostatic powder for GI bleeding has now been studied in an animal model and in a number of clinical case reports and series (TC-325 powder; Hemospray, Cook Medical, Winston...

The hemostatic spray was originally developed in the military to stop bleeding in the field and has since been applied to bleeding in the upper and lower gastrointestinal tract. The mineral material within the hemostatic spray is able to absorb fluid 30 to 40 times its dry weight, and a combination of fluid absorption, clotting, and coating the ...

2016年8月6日 · Our review highlights that hemostatic spray is a safe and effective method for endoscopic hemostasis, specifically, when current methods are infeasible, unsuccessful, and in malignant nonvariceal upper gastrointestinal bleeding.

1998年7月23日 · Many nontransfusional hemostatic drugs have been evaluated, but only a few have proven clinical efficacy. This article will review antifibrinolytic amino acids (aminocaproic acid and tranexamic...

2018年11月6日 · Hemostatic spray (Hemospray) is a newly available and FDA-approved topical option to control active bleeding. In a manufacturer-sponsored, prospective, multicenter study in Canada, 50 patients (including 6 on anticoagulants) with 52 sites of endoscopically confirmed lower GI bleeding were treated with hemostatic spray.

2020年6月15日 · Hemostatic spray is effective at controlling active bleeding and has a definite role in patients with refractory bleeding, bleeding from gastrointestinal malignancies, and bleeding in difficult locations.