OHT is supported by over 500 leading colleges and universities in 50 states, two living Presidents, NHL, NBA, MLB and major corporations. Operation Hat Trick continues to generate awareness, support and funding for the recovery of America’s wounded service members and veterans.

4-Hydroxytamoxifen ( (Z)-4-Hydroxytamoxifen) 是一种口服有效，选择性的雌激素受体调节剂 (SERM)。 4-Hydroxytamoxifen ( (Z)-4-Hydroxytamoxifen) 基于 ER 介导的细胞核易位诱导 CRISPR/Cas9 系统。 4-Hydroxytamoxifen ( (Z)-4-Hydroxytamoxifen) 也是 Tamoxifen (HY-13757A) 在体内的活性代谢形式，可用于诱导 CreER 转基因小鼠的基因敲除。 * Please select Quantity before adding items.

Compound: 4-OHT Antiproliferative activity against human tamoxifen-resistant T47D cells over-expressing PKC-alpha after 5 days by coulter counter analysis

4-羟基他莫昔芬(4-oht)是第一代选择性雌激素受体调节剂(serm)，在乳腺癌细胞中起拮抗剂作用，但在子宫和骨骼中可表现出雌激素样活性。 它是他莫昔芬(TAM)前药的活性代谢产物，发挥雌激素受体拮抗剂作用。

4-oht是有效的er激活剂，它对雌激素受体有更高的亲和力。 4-OHT具有较强的剂量和时间依赖式效应，能改变分离出来的大鼠心肌细胞的收缩功能 [1] 。 4-HT可激活intein-Cas9突变体的靶向修饰效率 [3] 。

4-羟基他莫昔芬(4-oht)是抗雌激素药物他莫昔芬在人和其他哺乳动物中的代谢产物。 Z型( 反式 )和E型( 顺式 )4-OHT异构体在未成熟大鼠中均具有抗雌激素作用。

2018年6月21日 · TAM is usually injected 24 hours before the behavior or stimulation, but 4-OFT is usually injected 2-4 hours after behavior or stimulation. Is it better to use 4-OHT than TAM to do FosTRAP...

4OHT treatment induces sequence-specific DSB induction in the AsiSI–ER U20S cell line. (A) U20S cells, which stably express AsiSI–ER–HA, were co-stained with DAPI (DNA) after incubation with...

2004年4月9日 · Treatment with OHT Induces Recruitment of ERα and NCoR to E-responsive Promoters—Tamoxifen behaves as an antiestrogen in the breast tissue (7). 4-Hydroxytamoxifen (OHT), an active cellular metabolite of tamoxifen, was used in this study. To explore the mechanisms underlying the inhibitory effects of OHT, we employed human MCF-7 …

提供 pBABe-HA-ER-IPpoI 载体/质粒图谱，全长序列，抗性，大小和元件信息。