The interaction and binding of ligand-receptor HA-CD44 regulate the downstream cytoskeleton pathways involve in cell survival or cell death. Thus, targeting HA, CD44 (variant and standard) isoform, and HA-CD44 binding consider as an attractive and …

An abundance of HMW HA can promote malignant cell proliferation and development of cancer, whereas antagonists to HA-CD44 signaling inhibit tumor cell growth in vitro and in vivo by interfering with HMW HA-CD44 interaction. This review describes the roles of HA interactions with CD44 and RHAMM in inflammatory responses and tumor development ...

CD44以HA依赖性或HA非依赖性参与调节 MMPs 表达，特别是MMP2和MMP9，降解细胞外基质（ECM），促进肿瘤的侵袭和转移。 CD44调节细胞周期相关蛋白的水平，包括细胞周期蛋白D和细胞周期蛋白A。 CD44可通过上调细胞周期素D1促进胃干细胞的增殖，推动细胞周期由G1期向S期进展。 CD44-ICD通过CREB（一种转录因子）上调cyclinD1的表达，加速甲状腺癌的细胞增殖。 CD44还能促进E-cadherin（上皮标记物）和 β-catenin 在质膜上的分离，促进释放的β …

因此，靶向 ha、cd44（变体和标准）同种型和 ha-cd44 结合被认为是一种有吸引力且有用的癌症治疗方法。 使用各种 HA 抑制剂、透明质酸酶 (HYAL)，以及利用靶向纳米递送抗癌剂和针对 CD44 的抗体，肽在体外和体内产生了有希望的结果。

ha-药物偶联物是利用可消除的化学键将药物与ha 偶联制备成前药，以改善药物的溶解度和药动学性质。 比如HA-PTX。 这个前药使H22细胞的细胞凋亡增加了5 倍，并且在CD44 受体介导内吞作用下增加了细胞摄取。

In this study, we have established quantitative relationships between CD44 expression in differently polarized macrophages (M0, M1, and M2-polarized THP-1 human macrophages) and the uptake of hyaluronic acid (HA)-based materials, which are …

2023年10月31日 · Hyaluronic acid (HA) receptor CD44 is widely used for identifying cancer stem cells and its activation promotes stemness. Recent evidence shows that overexpression of CD44 is associated with poor prognosis in most human cancers and mediates therapy resistance.

这篇综述描述了ha与cd44和rhamm相互作用在炎症反应和肿瘤发展/进展中的作用，以及如何在啮齿动物和人类疾病中开发出阻断这些关键炎症/致瘤过程的治疗策略。

先前我们已经证明，HMw-HA可以共价附于脂质纳米颗粒（NPs）的表面，赋予载体长循环并主动靶向在肿瘤上高度表达的HA受体（CD44和CD168）。在这里，我们介绍了一个由HA包覆的NPs组成的小型文库，其特征仅在于其表面锚定HA的Mw（范围为6.4 kDa至1500 kDa）。

2018年5月10日 · HA-drug bioconjugates, such as HA-Taxol, HA-CPT11, HA-Paclitaxel (PTX), and HA-polymer conjugates, can efficiently bind to CD44 overexpressing cancer cells and exert strong anti-proliferative activity on CD44 overexpressing cancer cells including human breast, colon, ovarian, gastric, breast, esophageal, and lung cancer cells as well as rat ...