2020年12月1日 · Preclinical model systems that mimic HPV infections are essential tools for investigations on viral etiology and pathophysiological processes of human diseases. Herein, we describe different PV infection model systems in animals, …

2015年10月12日 · Human papillomaviruses (HPVs) cause a range of serious diseases, including the vast majority of cervical cancers, most anal cancers and around half of head and neck cancers.

2024年11月22日 · We develop a deterministic mathematical model to investigate the transmission dynamics of human papillomavirus (HPV) and its impact on cervical cancer.

2024年7月5日 · Here, we introduce the Human papillomavirus simulator (HPVsim), a new open-source software package for creating flexible agent-based models parameterised with country-specific vital dynamics, structured sexual networks, and co-transmitting HPV genotypes.

2017年5月2日 · HPVs are double-stranded DNA viruses and can be recognized by PRRs, namely Toll-like receptors (TLR). Among this family of PRRs, TLR-9 is present in the membrane of endolysosomes and detects CpG-DNA from microorganisms like viruses (e.g. HPV), bacteria and protozoa (Takeuchi and Akira, 2010).

2020年5月12日 · In this paper, we describe an infection-based HNSCC model, utilizing a mouse papillomavirus (MmuPV1), which naturally infects laboratory mice. Infections of the tongue epithelium of two immunodeficient strains with MmuPV1 caused high-grade squamous dysplasia with early signs of invasive carcinoma over the course of 4 months.

2023年6月12日 · In this study, we have developed two animal models, with a genetic design that is easily transposable to different antigens, to validate the efficacy of candidate vaccines. Our results indicate that, despite being immunogenic, the C216 candidate vaccine did not induce a sufficiently strong immune response to eliminate infected cells.

2014年10月12日 · The cervicovaginal challenge infection model with HPV PsV can induce long-lived tissue resident memory CD8 T cells located in the cervicovaginal epithelium. Therefore, the model constitutes not only an opportunity for vaccination against genital infection but also provides an experimental model to study the biology of genital tissue resident ...

2017年5月2日 · For decades, research on the pathogenesis of papillomavirus-induced lesions, particularly of human papillomavirus (HPV) has relied on the use of animal models. Among these, HPV-transgenic mice are some of the most frequently employed.

Using this mathematical model we evaluated the impact of human papillomavirus (HPV) on a given population and determined what could decrease the rate at which AAW become infected. All state equations in the model were approximated using the Runge-Kutta 4(th) order numerical approximation method using MatLab software.