2025年3月30日 · HMGA1 (High Mobility Group AT-Hook 1) is a Protein Coding gene. Diseases associated with HMGA1 include Type 2 Diabetes Mellitus and Lipomatosis, Familial Multiple. Among its related pathways are HIV Life Cycle and Infectious disease.

HMGA1 proteins are quite small (~10-12 kDa) and basic molecules, and consist of three AT-hooks with the RGRP (Arg-Gly-Arg-Pro) core motif, a novel cross-linking domain located between the second and third AT-hook, and a C-terminal acidic tail characteristic for the HMG family comprising HMGA, HMGB and HMGN proteins.

2024年12月27日 · 本文将详细介绍HMGA1基因的功能、作用机制、信号通路以及与疾病的关系，帮助读者全面理解这一重要的基因。 HMGA1基因，全称为 high mobility group AT-hook 1，位于染色体 6p21.31。 它编码一个蛋白质产物，属于 Canonical high mobility group 家族，同时也是 MicroRNA protein coding host genes 的一部分。 这个基因在许多生物过程中扮演着关键角色，尤其是在DNA结构和基因表达调控方面。 HMGA1基因的主要功能是 调控基因表达。 它通过 …

High mobility group A1 (HMGA1) is a nonhistone chromatin structural protein characterized by no transcriptional activity. It mainly plays a regulatory role by modifying the structure of DNA. A large number of studies have confirmed that HMGA1 ...

2024年8月12日 · Here, we combine functional genomics approaches with graph theory to investigate how HMGA1 genomic deposition controls high-order chromatin networks in an oncogene-induced senescence model. While...

2025年2月3日 · In human colon cancer cells, HMGA1 directly induces ASCL2 by recruiting activating histone marks. Silencing HMGA1 disrupts oncogenic properties, whereas reexpression of ASCL2 partially rescues these phenotypes. Further, HMGA1 and ASCL2 are coexpressed and upregulated in human colorectal cancer.

We demonstrate that, in a triple-negative breast cancer cellular model, HMGA1 sustains the action of epigenetic modifiers and in particular it positively influences both histone H3S10 phosphorylation by ribosomal protein S6 kinase alpha-3 (RSK2) and histone H2BK5 acetylation by CREB-binding protein (CBP).

该基因编码一种染色质相关蛋白，参与基因转录调控、逆转录病毒整合到染色体中以及癌细胞的转移进程。 编码的蛋白质优先结合双链 DNA 中富含 AT 区域的小沟。 已发现该基因编码不同异构体的多个转录变体。 已在多条染色体上鉴定出该基因的假基因。 [RefSeq 提供，2016 年 1 月] This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of Cancer cells.

2022年7月4日 · 高迁移率组 A1 (HMGA1) 是一种非组蛋白染色质结构蛋白，其特征是没有转录活性。 它主要通过修饰DNA的结构来发挥调节作用。 大量研究证实，HMGA1调控生殖系统、消化系统、泌尿系统和造血系统肿瘤相关基因。 HMGA1 在成体细胞中很少见，在胚胎等高度增殖的细胞中增加。 受外界因素刺激后，会通过Wnt/β-catenin、PI3K/Akt、Hippo和MEK/ERK通路产生作用。 此外，HMGA1还影响癌细胞的衰老、凋亡、自噬和化疗耐药，这些与肿瘤发生有关。 在这 …

2017年8月4日 · HMGA1 promotes tumor growth by several mechanisms, including increase of cell proliferation and survival, impairment of DNA repair and induction of chromosome instability. Autophagy is a...