Henry Gustav Molaison (February 26, 1926 – December 2, 2008), known widely as H.M., was an American who had a bilateral medial temporal lobectomy to surgically resect the anterior two thirds of his hippocampi, parahippocampal cortices, entorhinal cortices, piriform cortices, and amygdalae in an attempt to cure his epilepsy.

抛开“h.m.”这个名字，亨利只是一个普通的患者，他会开玩笑，会因帮助别人而开心，也会因自己“秒忘”而痛苦。 日常生活中，亨利是一个善良友好的人，同他接触过的科研人员都认为他彬彬有礼，颇有风度，还有几分幽默感。

2014年1月28日 · Our study also reveals diffuse pathology in the deep white matter and a small, circumscribed lesion in the left orbitofrontal cortex. The findings constitute new evidence that may help elucidate...

1997年5月15日 · Although neuropsychological studies of the amnesic patient H. M. provide compelling evidence that normal memory function depends on the medial temporal lobe, the full extent of his surgical resection has not been elucidated. We conducted magnetic resonance imaging studies to specify precisely the ex …

The autopsy photographs showed the dense scar tissue in H.M.’s lesion and the marked cerebellar atrophy, while the MRI data, including in situ and ex vivo images, capitalized on improved contrast and resolution to reveal the lesion shape (or remaining tissue shape) and the precise measurements for lesion size.

What is it about H. M.’s lesion that has caused such a profound memory impairment? H. M.’s resection eliminated the entire medial temporal polar cortex (Filimonoff area TG, Brodmann area 38), virtually the entire amygdaloid complex, essentially all of the entorhinal cortex, and at least half of the intraventricular portion of the ...

2018年8月28日 · In 1955, scientists William Beecher Scoville and Brenda Milner began studying Molaison — referred to as H.M. to protect his privacy — and nine other patients who had undergone similar surgery. Only patients who had specific portions of their medial temporal lobes removed experienced memory problems.

H.M. is probably the best known single patient in the history of neuroscience. His severe memory impairment, which resulted from experimental neurosurgery to control seizures, was the subject of study for five decades until his death in December 2008.

H.M., Henry Molaison, was one of the world's most famous amnesic patients. His amnesia was caused by an experimental brain operation, bilateral medial temporal lobe resection, carried out in 1953 to relieve intractable epilepsy. He died on December 2, 2008, and that night we conducted a …

2013年4月22日 · EP's story is strikingly similar to the more famous case of HM, who also suffered permanent, dramatic memory loss after small portions of his medial temporal lobes were removed by doctors in 1953...