DRB1 encodes the most prevalent beta subunit of HLA-DR. DRB1 alleles, especially those encoding amino acid sequence changes at positions 11 and 13, are associated risk of …

2025年3月30日 · HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) is a Protein Coding gene. Diseases associated with HLA-DRB1 include Multiple Sclerosis and Sarcoidosis …

2024年11月13日 · HLA-DRB1属于II类HLA，其产物蛋白和HLA-DRA1蛋白形成异二聚体，展示长度为13-25个氨基酸的多肽。 而HLA-DRB3/4/5表达产物与HLA-DRB1有较高同源性，同样 …

Gene ID: 3123, updated on 8-Feb-2025. HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta …

The HLA-DRB1 gene provides instructions for making a protein that plays a critical role in the immune system. The HLA-DRB1 gene is part of a family of genes called the human leukocyte …

Association studies of the HLA-DRB1 gene clearly indicate its importance in RA morbidity. This review presents the current state of knowledge on the impact of HLA-DRB1 gene, functioning …

HLA-DRB1 属于 HLA II 类β链旁系同源物。 II 类分子是由 alpha (DRA) 和 beta 链 (DRB) 组成的异二聚体，两者都锚定在膜中。它通过呈递源自细胞外蛋白的肽在免疫系统中发挥核心作用。 II …

The human leukocyte antigen (HLA) DRB1*1501 has been consistently associated with multiple sclerosis (MS) in nearly all populations tested. This points to a specific antigen presentation as …

2025年2月8日 · Gene target information for HLA-DRB1 - major histocompatibility complex, class II, DR beta 1 (human). Find diseases associated with this biological target and compounds …

II类分子是一个由α（DRA）和β链（DRB）组成的核心异二聚体，两者都固定在膜上。 它通过呈现来自细胞外蛋白的肽来在免疫系统中发挥核心作用。 II类分子在抗原呈递细胞中表达。 β链约 …