HLA-C is a locus on chromosome 6, which encodes for many HLA-C alleles that are Class-I MHC receptors. HLA-C, localized proximal to the HLA-B locus, is located on the distal end of the HLA region. Most HLA-C:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.

HLA研究中，模拟免疫反应激活的过程，就要经过 蛋白酶体对抗原（蛋白）的剪切预测 、肽段转运、 肽段和MHC-I结合亲和力预测 以及 T细胞识别预测 等几个重要步骤。 一般可以采用滑动窗口（sliding windows）的方法把可能的肽段都提取出来，MHC结合亲和力预测由软件实现（但效果各有说法，最好多重比较筛选， 软件对比），更严谨的可以用抗原实验来验证（制造目标肽段，做实验查看与MHC的结合情况）。 HLA配型也叫移植配型，HLA基因座位点具有高度多态性，完 …

2024年12月25日 · HLA-C (Major Histocompatibility Complex, Class I, C) is a Protein Coding gene. Diseases associated with HLA-C include Psoriasis 1 and Human Immunodeficiency Virus Type 1. Among its related pathways are SARS-CoV-2 Infection and Infectious disease. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and …

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen.

hla-c是人類白細胞抗原（hla）的一个基因座，位于6号染色体上。 成熟的HLA-C蛋白会与 β2微球蛋白 组成异二聚体，作为一个受体锚定在细胞表面。 参考文献

2021年11月10日 · HLA-C is the most recently evolved HLA class I molecule, only present in humans and great apes. Differentiating from its older siblings, HLA-A and HLA-B, HLA-C exhibits distinctive features in its expression and interaction partners.

HLA-C is the only HLA class I molecule that is expressed on trophoblasts, which can be recognized by maternal decidual NK cells, and therefore represent a key molecule for the maternal-fetal immune tolerance in the establishment of pregnancy [11].

2023年7月2日 · HLA-C, a gene located within the major histocompatibility complex, has emerged as a prominent target in biomedical research due to its involvement in various diseases, including cancer and autoimmune disorders; even though its recent addition to the MHC, the interaction between HLA-C and KIR is crucial for immune responses, particularly in ...

HLA-C是 人类白细胞抗原 （HLA）的一个 基因座，位于 6号染色体 上。 成熟的HLA-C蛋白会与 β2微球蛋白 组成异二聚体，作为一个受体锚定在 细胞表面。 Illustration of an HLA-C showing the HLA-B 'alpha' chain,?2-Microglobulin, and the end of a peptide bound in the binding cleft. HLA-C是人类白细胞抗原（HLA）的一个基因座，位于6号染色体上。 成熟的HLA-C蛋白会与β2微球蛋白组成异二聚体，作为一个受体锚定在细胞表面。

HLA 系统在传染病的发生和结果中起着重要作用，包括由疟原虫、人类免疫缺陷病毒 (HIV) 和严重急性呼吸系统综合症冠状病毒 (SARS-CoV) 引起的传染病。 据报道，导致 2019 年冠状病毒病 (COVID-19) 的新型冠状病毒 SARS-CoV-2 的结构尖峰和核衣壳蛋白包含多个具有预测 HLA 限制的 I 类表位。 个体 HLA 遗传变异可能有助于解释人群对病毒的不同免疫反应。 [RefSeq 提供，2020 年 8 月] HLA-C belongs to the HLA class I heavy chain paralogues.