HLA-B57 (B57) is an HLA-B serotype. B57 is a split antigen from the B17 broad antigen, the sister serotype being B58. [2] The serotype identifies the more common HLA-B*57 gene products. [1] (For terminology help see: HLA-serotype tutorial.) Like B58, B57 is involved in drug-induced inflammatory skin disorders.

2018年11月8日 · Here we explore the impact of micropolymorphism on peptide antigen presentation by three closely related HLA molecules, HLA-B*57:01, HLA-B*57:03 and HLA-B*58:01, that are differentially...

HIV control is strongly associated with the expression of human leukocyte antigen (HLA) alleles in HICs. From the HIV protective HLAs described, HLA-B57 is the most frequent in HIC patients. HLA-B57 can present a large range of highly conserved Gag-derived HIV peptides to CD8 + T cells and natural killer (NK) cells, both the focus of this ...

HLA types associated with slow progression of the infection such as HLA-B27 and HLA-B57 stimulate more effective immune responses compared with those that confer increased susceptibility such as HLA-B35. Similarly, homozygosity at the HLA class 1 loci, which is also associated with more rapid progression of HIV, offers less opportunity for a ...

HLA-B57 has been associated with slower disease progression in HIV infection, and interestingly, functional differences in HIV immunity are observed in individuals who are HLA-B*5701 + or HLA-B*5703 + that respond to the same HIV determinant.

2008年12月30日 · HLA-B57 and the closely related allele B*5801 are particularly associated with enhanced control and recognize the same Gag 240-249 TW10 epitope. The typical escape mutation (T242N) within this epitope diminishes viral replication capacity in chronically infected persons; however, little is known about TW10 epitope sequences in residual ...

Through this process, we identified HLA-B57:01:01.B2m open format as a very promising candidate and demonstrate that an optimization by 2 point mutations resulted in a lead candidate (HLA-B57 (A46E/V97R).B2m-IgG4_Fc, called IOS-1002) with superior expression and with specific and avidity-driven binding to LILRB1, LILRB2, KIR3DL1 and CD64 and ...

2018年11月8日 · Immunophenotypic differences between closely related human leukocyte antigen (HLA) alleles have been associated with divergent clinical outcomes in infection, autoimmunity, transplantation and drug hypersensitivity. Here we explore the impact of micropolymorphism on peptide antigen presentation by t …

2018年11月8日 · hla - b57家族成员以其与hiv感染者精英控制表型的关联而闻名21、22。hla - b57的保护作用被假设是由于免疫原性hiv肽比非保护性hla变体(具有不同的肽结合特性)更有效地呈现给抗病毒细胞毒性t淋巴细胞。

HLA-B*57 is the HLA allele that has the greatest impact on the viral-load set point and the rate of disease progression in HIV infection (10, 17, 18, 23, 28, 29, 34, 42, 46, 55). However, critically for the development of a vaccine designed to optimize immune control of HIV infection, the mechanism by which HLA-B*57 is linked to relatively ...