There are three major and two minor MHC class II proteins encoded by the HLA. The genes of the class II combine to form heterodimeric (αβ) protein receptors that are typically expressed on the surface of antigen-presenting cells. Major MHC class II proteins only occur on antigen-presenting cells, B cells, and T cells. [1] HLA-DP

hla-i和ii不同基因座位上分别编码的基因产物，称之为hla复合体抗原，表达在细胞表面，呈凸起状。 HLA的生物学功能不仅限与诱导同种异体组织或器官移植排斥反应相关，而且参与免疫应答的调控，如MHC限制性、抗原转递、补体产生等。

The biological role of the HLA class I and class II molecules is to present processed peptide antigens. The HLA system is clinically important as transplantation antigens. Molecular HLA allele typing is routinely performed to provide HLA class I and class II allele matching in unrelated donor hematopoietic stem cell transplantation.

2013年7月18日 · The main function of HLA class I gene products (HLA-A, -B, and -C) is to present endogenous peptides to responding CD8+ T Cells while the class II coded molecules HLA-DR, -DP, and –DQ have restricted expression and process exogenous peptides for presentation to CD4+ helper T Cells.

The biologic significance of HLA class I and class II molecules in the development of an efficient immune system that permits our survival in the sea of microorganisms in which we are immersed is illustrated by the severe and lethal infections that occur when these antigens are absent.

HLA class II molecules are present on the surface of antigen-presenting cells (APC), such as macrophages, B cells, and dendritic cells, and display short antigen peptides to CD4 + helper T cells and their receptors .

2019年10月14日 · Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II molecules would be valuable for vaccine development and cancer immunotherapies. Current computational...

Here, we employed monoallelic immunopeptidomics to identify 358,024 HLA-II binders, with a particular focus on HLA-DQ and HLA-DP. We uncovered peptide binding patterns across a spectrum of binding affinities and enrichment of structural antigen features.

The MHC class I and class II molecules are the most immunogenic antigens that are recognized during rejection of an allogeneic transplant. The strongest determinant is HLA-DR, followed by HLA-B and HLA-A. These 3 loci are therefore the most …

2023年4月24日 · Human leukocyte antigens are of three main types. Class I HLA antigens include HLA-A, B, and C molecules; class II, which includes HLA-DR, -DQ, and -DP loci, are on antigen-presenting cells; and class III contains genes for proteins that have immune functionality.