2025年3月30日 · HK3 (Hexokinase 3) is a Protein Coding gene. Diseases associated with HK3 include Long Qt Syndrome. Among its related pathways are glycolysis (BioCyc) and GDP-glucose biosynthesis II. Gene Ontology (GO) annotations related to this gene include enzyme binding and phosphotransferase activity, alcohol group as acceptor.

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Hexokinase III, also known as hexokinase C, is an enzyme which in humans is encoded by the Hk3 gene on chromosome 5. [5] [6] Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Similar to hexokinases I and II, this allosteric enzyme is inhibited by its product glucose-6-phosphate.

人体中己糖激酶有四种同工酶， 1型同工酶（hk1）主要分布在脑，hk2主要分布在骨骼肌，hk3主要分布在白细胞，hk4主要分布在肝脏。 因为HK4与另外三种同工酶差异较大，对葡萄糖的特异性强，所以又被称为葡萄糖激酶（glucokinase）。

2022年5月11日 · Our findings provide evidence that HK3 is dispensable for glycolytic activity in AML cells while promoting cell survival, possibly through direct interaction with the BH3-only protein BIM during...

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes Hexokinase 3. Similar to hexokinases 1 and 2, this allosteric Enzyme is inhibited by its product glucose …

2024年8月23日 · Our research identified that the glycolysis-related gene (GRG) HK3 has a unique correlation with PD-L1 expression. HK3 has been identified as a key regulator of O-GlcNAcylation in ccRCC....

HK3是哺乳动物细胞中四个高度同源的己糖酶同工型之一。 该蛋白的分子量为100 kDa，由两个高度相似的50 kDa结构域组成，其 N 和 C末端。 这种高度相似性以及50 kDa己糖酶（ HK4 ）的存在表明，100 kDa己糖苷酶源自 基因重复 和串联连接的50 kDa前体。 与 HK1 一样，只有C末端结构域具有催化能力，而N末端结构域预计包含 葡萄糖 和 G6P 结合位点，以及对于适当 蛋白质折叠 所必需的32个 残基 区域。 此外，催化活性取决于两个末端结构域之间的相互作用。 与HK1和 …

2024年12月31日 · HK3 emerges as a novel prognostic biomarker for HCC, exerting regulatory influence over cellular proliferation, metastasis, and invasiveness. These findings indicate that HK3 holds promise as a potential candidate for treatment and prognosis of HCC.

什么是HK3基因？ HK3基因，全名为hexokinase 3，位于人类染色体5q35.2区域。这个基因的主要任务是指导合成一种叫做hexokinase的酶，这种酶在细胞的能量代谢中扮演着至关重要的角色。 HK3基因的功能