HIV is different in structure from other retroviruses. The HIV virion is ~100 nm in diameter. Its innermost region consists of a cone-shaped core that includes two copies of the (positive sense) ssRNA genome, the enzymes reverse transcriptase, integrase and protease, some minor proteins, and the major core protein. [8] .

On the basis of genetic characteristics and differences in the viral antigens, HIV is classified into the types 1 and 2 (HIV-1, HIV-2). The immunodeficiency viruses of non-human primates (simian immunodeficiency virus, SIV) are also grouped to the genus Lentivirus.

2021年6月24日 · HIV host genomic research, which aims to understand how human genetic variation affects our response to HIV infection, has progressed from early candidate gene studies to recent multi-omic...

The “vif” gene codes for “virion infectivity factor”, a protein that increases the infectivity of the HIV particle. The protein is found inside HIV-infected cells, and it works by interfering with one of the immune system’s defences – a cellular protein called APOBEC3G.

In an effort to discover host factors required for HIV replication, identify critical pathogenic pathways, and reveal the full armament of host defenses, there has been a shift from candidate gene studies to unbiased genome wide genetic and functional studies.

2025年1月15日 · Human immunodeficiency virus-1 (HIV-1) uses a number of strategies to modulate viral and host gene expression during its life cycle. To characterize the...

2025年3月26日 · The HIV-1 polymerase (pol) gene sequences obtained from the collected samples will be used to perform phylogenetic analysis and characterize the genetic subtypes’ molecular transmission networks.

2017年12月1日 · Genome of HIV consists of 9 gene, 3 structural gene and 6 non-structural gene (regulatory gene). Structural gene (env,gag and pol), regulatory gene (tat,rev,nef,vif,vpr and vpu in HIV-I and vpx in HIV-2)

Human immunodeficiency virus-1 (HIV-1) uses a number of strategies to modulate viral and host gene expression during its life cycle. To characterize the transcriptional and translational landscape of HIV-1 infected cells, we used a combination of ribosome profiling, disome sequencing and RNA sequenc …

2025年3月29日 · In contrast to human endogenous retroviruses, HIV-1 proviral integration or components of HIV-1, such as regulatory or accessory proteins, can interact with the human genome, leading to DNA damage or gene dysregulation.