Hfe-KO - 南模生物
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重 …
Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe …
2011年1月27日 · We hypothesize that HFE modulates erythropoiesis by affecting dietary iron absorption and erythroid iron intake. To investigate this, we used Hfe -KO mice in conditions of …
Iron overload in a murine model of hereditary hemochromatosis is ...
Results: Hfe-KO mice showed a systemic iron overload and an increased iron accumulation in the knee synovial membrane following surgery. The histological OA score was significantly higher …
Bone morphogenetic protein signaling is impaired in an Hfe …
We investigated whether HFE is involved in BMP6-SMAD regulation of hepcidin expression. The BMP6-SMAD pathway was examined in Hfe knockout (KO) mice and in wild-type (WT) mice …
178. Successful Reversion of the Hemochromatosis Phenotype in Hfe-KO …
In summary, we have developed a new tool for gene therapy that increases expression of Hamp in the liver, partially reversing the hemochromatosis phenotype. Finally, studies are in progress …
Intracellular iron uptake is favored in Hfe‐KO mouse primary ...
2019年5月27日 · Our data provide evidence that both wt- and Hfe -KO-derived chondrocytes, when exposed to 50 μM iron, develop characteristics of an OA-related phenotype, such as an …
Accelerated Transferrin Degradation in HFE-Deficient
2006年12月1日 · To examine how HFE might influence transferrin catabolism, we studied HFE-deficient mice. B2m-KO and HFE-KO mice rapidly degraded transferrin and the rapid …
Hfe Modulates the Response to Erythopoietic Stress In Wt Mice …
2010年11月19日 · We hypothesized that Hfe influences erythropoiesis by two distinct mechanisms: 1) limiting hepcidin expression, thereby increasing iron availability, under …
Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe …
We hypothesize that HFE modulates erythropoiesis by affecting dietary iron absorption and erythroid iron intake. To investigate this, we used Hfe -KO mice in conditions of altered dietary …
Iron-enriched diet contributes to early onset of osteoporotic ... - PubMed
2018年11月14日 · Osteoporosis is associated with chronic iron overload secondary to hereditary hemochromatosis (HH), but the causative mechanisms are incompletely understood. The main …