Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene. [5][6][7] Histones play a critical role in transcriptional regulation, cell cycle progression, and …

2025年3月30日 · HDAC8 (Histone Deacetylase 8) is a Protein Coding gene. Diseases associated with HDAC8 include Cornelia De Lange Syndrome 5 and Cornelia De Lange Syndrome. …

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences …

The HDAC8 gene provides instructions for making an enzyme called histone deacetylase 8. This enzyme is involved in regulating the structure and organization of chromosomes during cell …

2024年12月15日 · HDAC8 has emerged as an important target in the field of pharmacology. This review summarizes the latest advancements and clinical research on HDAC8 inhibitors and …

2015年7月1日 · Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and …

2019年2月15日 · This review is concerned about the structural and positional aspects of HDAC8 in the HDAC family. It also covers the contributions of HDAC8 in the pathophysiological …

2022年10月9日 · Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone and non-histone proteins. As one of the best-characterized isoforms, …

2020年9月4日 · Histone deacetylase 8 (HDAC8), a class I HDAC that modifies non-histone proteins such as p53, is highly expressed in different hematological neoplasms including a …

2025年2月8日 · Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the …