Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. [5][6] It is the only …

瘤免疫、移植免疫、自身免疫疾病中发挥重要作用,是免疫治疗的重要靶点。该文就HDAC11的生物学特性、免疫调控�. 能、在免疫相关性疾病中的作用及其抑制剂开发的最新研究进展作一综 …

The histone deacetylases (HDACs) family of enzymes possess deacylase activity for histone and nonhistone proteins; HDAC11 is the latest discovered HDAC and the only member of class IV. …

2022年3月12日 · This study provided evidence that HDAC11 is highly expressed in the aortic intima of HFD-fed ApoE −/− mice and HDAC11 knockdown significantly suppressed pyroptosis …

HDAC8和HDAC11则优先水解非乙酰酰基赖氨酸底物，HDAC10则是一种多胺去乙酰化酶。 乙酰赖氨酸底物位于一个由疏水残基围绕的狭窄通道中，其中酪氨酸残基通过构象翻转与羰基氧形 …

2024年12月25日 · HDAC11 (Histone Deacetylase 11) is a Protein Coding gene. Diseases associated with HDAC11 include Mature T-Cell And Nk-Cell Lymphoma and Peripheral T-Cell …

2023年10月1日 · HDAC11 may promote tumor development and progression by regulating biological characteristics such as cell invasion, migration, stemness, apoptosis, and immune …

2023年9月3日 · Histone deacetylase 11 (HDAC11) is a unique member of the histone deacetylase family that plays an important role in the regulation of gene expression and …

HDAC11 shows tissue and cell type-specific expression, encompassing innate and adaptive immunity cell types. HDAC11 represses anti-inflammatory IL10 interleukin gene transcription. …

HDAC11 demyristoylation is the most efficient HDAC hydrolytic activity in vitro. Histone deacetylase (HDAC) enzymes regulate diverse biological function, including gene expression, …