HDAC1 - Wikipedia
Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene. [5] Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in …
组蛋白去乙酰化酶 - 百度百科
组蛋白去乙酰化酶 (histone deacetylase,HDAC)是一类蛋白酶,对染色体的结构修饰和基因表达调控发挥着重要的作用。 一般情况下,组蛋白的乙酰化有利于DNA与组蛋白八聚体的解离，核小体 …
HDAC1 Gene - GeneCards | HDAC1 Protein | HDAC1 Antibody
2025年3月30日 · HDAC1 (Histone Deacetylase 1) is a Protein Coding gene. Diseases associated with HDAC1 include Hematologic Cancer and Epilepsy. Among its related pathways are RNA …
一文带你了解组蛋白去乙酰化酶（HDAC） - 知乎专栏
11种hdac为锌依赖型金属酶（hdac1−11），通过以水分子作为亲核试剂水解酰胺键； 7种脱乙酰化酶为 Sirtuins （Sirt1−7），利用NAD+作为辅因子，将酰基转移至核糖糖环的C2位。
HDAC1: an environmental sensor regulating endothelial function
2022年6月29日 · In the endothelium, HDAC1 mediates the effects of external and environmental stimuli by regulating major endothelial functions such as angiogenesis, inflammatory …
EGFR phosphorylates HDAC1 to regulate its expression and anti …
2021年5月11日 · HDAC1 is the prototypical human histone deacetylase (HDAC) enzyme responsible for catalyzing the removal of acetyl group from lysine residues on many substrate …
Histone deacetylase (HDAC) 1 and 2 complexes regulate both
2018年10月2日 · Here we show that Histone Deacetylase 1 and 2 (HDAC1/2), the catalytic core of numerous co-repressor complexes, are important histone decrotonylase enzymes. A ternary …
The histone deacetylase HDAC1 controls dendritic cell ... - Cell Press
Multi-omics analyses reveal that HDAC1 controls expression, chromatin accessibility, and histone acetylation of the transcription factors IRF4, IRF8, and SPIB required for efficient development …
HDAC1 | histone deacetylases | 组蛋白脱乙酰基酶 | 关键调控因子
2021年3月17日 · A Comparative Study of Target Engagement Assays for HDAC1 Inhibitor Profiling. Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the …
ARS丨王福俤团队揭示HDAC1去乙酰化酶调控机体铁稳态新机制
2017年11月14日 · 该研究通过筛选表观遗传调控小分子库，发现entinostat（MS-275）作为一型组蛋白去乙酰化酶（HDAC1）抑制剂，能够上调血色病模型Hfe-/-鼠中的铁调素水平和缓解肝组 …