2023年6月9日 · Acetazolamide improves decongestive response over the entire range of HCO3- levels; however, the treatment response is magnified in patients with baseline or loop diuretic-induced elevated HCO3 (marker of proximal nephron NaHCO3 retention) by specifically counteracting this component of diuretic res …

2023年7月2日 · Acetazolamide modulates the abnormal GABA-A-mediated depolarization that generates epileptic waves and has been shown to block epileptiform activity by inhibiting HCO3 -efflux. The integration of the above-illustrated mechanisms …

2017年1月6日 · Acetazolamide is a carbonic anhydrase (CA) inhibitor sometimes used as a respiratory stimulant for patients with chronic obstructive pulmonary disease (COPD) with the goal of improving oxygenation, reducing carbon dioxide retention, and aiding liberation from mechanical ventilation and/or attempting to correct a metabolic alkalosis.

Carbonic anhydrase inhibitors such as acetazolamide cause a mild metabolic acidosis and may stimulate breathing. Some patients with severe chronic obstructive pulmonary disease (COPD) develop chronic hypercapnic ventilatory failure. In theory, they ...

乙酰唑胺，化学名称为N- (5-氨磺酰基-1,3,4-噻二唑-2-基)乙酰胺，是一种 有机化合物，化学式为4H6N4O3S2，主要用作利尿药、碳酸酐酶抑制剂，服后抑制肾小管上皮细胞中的碳酸酐酶，使H2CO3的形成减少，H + 的产生随之下降。 因此，H + 与Na + 的交换大为减慢，结果HCO3 - 、Na + 、K + 排出增加，尿量增多，也能抑制房水分泌过程，使眼压下降，还可用于治疗青光眼，轻度心脏性水肿等。 乙酰唑胺为利尿药、碳酸酐酶抑制剂，服后抑制肾小管上皮细胞中的碳酸 …

2016年5月5日 · Compensation for metabolic alkalosis is suppression of respiration to allow the carbon dioxide to accumulate reducing the change in pH. Suppressing respiration is obviously a concern in patients on the vent. One option in this situation is to treat the metabolic alkalosis.

Methods: Fifteen consecutive intensive care unit patients with metabolic alkalosis (pH > or = 7.48 and HCO3- > or = 28 mmol/l) were treated with a single administration of 500 mg acetazolamide intravenously. Serum levels of strong ions, creatinine, lactate, weak acids, pH and partial carbon dioxide tension were measured at 0, 12, 24, 48 and 72 ...

Objective: To describe the acetazolamide regimen and outcomes in critically ill children with metabolic alkalosis. Methods: This was a descriptive, retrospective study of patients <18 years of age who received ≥3 doses of acetazolamide for metabolic alkalosis (ie, pH > 7.45 and bicarbonate [HCO3] > 26 mEq/L). Patients receiving other ...

丹木斯(Diamox,acetazolamide)，在上山前一天就開始服用，每天早晚使用125 毫克(或者以體重計算每天每公斤5 毫克，分成2-3 次使用)，使用到不再上升的高度後繼續再 ...

2020年7月25日 · H2CO3 is converted to H and HCO3 in the cytoplasm, and HCO3 reabsorbed on the interstitial membrane with Na, and H secreted via Na/K transporter on the luminal membrane; By blocking this enzyme, CAIs blunt NaHCO3 reabsorption and cause diuresis; They also reduce renal secretion of H in the PCT; Pharmacokinetics. Well absorbed orally