Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene. [5][6][7][8] There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian heart. [9] .

该基因的突变与病态窦房结综合征 2 有关，也称为房颤伴心动过缓或家族性窦性心动过缓。 已在 15 号染色体上鉴定出两个假基因。 [RefSeq 提供，2008 年 10 月] This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process.

2025年3月30日 · HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4) is a Protein Coding gene. Diseases associated with HCN4 include Sick Sinus Syndrome 2 and Brugada Syndrome 8. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses.

2025年3月1日 · HCN4, the predominant HCN channel expressed in cardiac sinoatrial nodal (SAN) pacemaker cells, initiates each normal heartbeat by a cell membrane depolarizing inward current (I f) 5 that triggers...

2025年2月8日 · HCN4 associates with Cav3 to form a HCN4 macromolecular complex. Our results also indicated that disruption of caveolae using P104L alters HCN4 function and could cause a reduction of cardiac pacemaker activity. A mouse model for a loss-of-function study of HCN4, which has a strong implication for the function of the related human protein.

2018年2月12日 · HCN4 mutations confer diverse phenotypes, characterized by the previously described bradycardia, sick sinus syndrome, LVNC, mood and anxiety disorders, and susceptibility to VF as described here.

HCN通道 共有4种：HCN1, HCN2, HCN3, 和HCN4。 自从HCN通道被发现后，它的超极化激活特性立即引起了科学研究者的重视。 HCN通道参与了许多神经活动,包括参与调节神经元活动的节律性和树突整合，调控细胞静息膜电位及突触传递等等。 其中 Ih 在调节神经元内在兴奋性和突触传递上有重要作用，它既可以促进胚胎干细胞的增殖，也能处理外层视网膜的光反馈信号。 另外，有研究发现苍白球中的突触后电流Ih能够抑制谷氨酸能和GABA能的突触传递，这表明HCN通道 …

The HCN4 gene provides instructions for making a channel that transports positively charged atoms (ions) into heart muscle cells. This channel is located primarily in the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker.

The HCN4 gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated ion channel family, which are expressed at the cell membrane and contribute to the resting membrane potential. HCN4 is expressed in the heart and in several brain regions, including the thalamus (summary by Campostrini et al., 2018). Cloning and Expression

The HCN4 channels are responsible for the hyperpolarization activated funny current (If) essential to sinoatrial node automaticity. They are highly expressed in the sinus node, with mutations in the HCN4 gene also found to be associated with familial SND.