Hb Setif (or HBA2: c.283G>T) is one of these variants with a mutation at codon 94 of of the α2-globin gene that is characterized in clinically normal heterozygous individuals. We here report clinical and hematological findings in two homozygous cases of …

Hb Setif [94 (G1) Asp → Tyr] is another α-chain Hb variant. This Hb has electrophoretic mobility similar to Hb S at alkaline pH 29 , 30 . In studies from Kurdish population of Western Iran this Hb variant was the third prevalent structural variant of Hb.

Hb Setif is a relatively rare, mildly unstable alpha2-globin hemoglobin (Hb) variant first described in an Algerian family, and subsequently in various populations of the Mediterranean region and the Middle East. Hb Agrinio is a highly unstable variant, …

1972年11月1日 · A new example of disturbance of this hydrogen bond is reported in this paper: in Hb Setif, the residue Asp G 1 (94)ca is substituted by a tyrosine. Moreover, the fact that the abnormality lies on the a chain and that the new residue is a tyrosine, bears a genetic interest.

Hb Setif is a rare type of hemoglobinopathy resulting from an aspartic acid to tyrosine substitution at codon 94 (GAC>TAC) of the α2-globin gene. In manual and automated hemoglobin (Hb) electrophoresis examination of the case, an unusual band was detected and the result of subsequent capillary electrophoresis suggested that to be Hb Setif.

Hemoglobin Setif produces pseudosickling of red cells in vitro; the nature of the process and the conditions that “trigger” it are unknown. Studies of red cells, hemolysates, purified hemoglobin solutions, and artificial mixtures of Hb A and Setif suggest that pseudosickling is produced by intracellular crystallization of insoluble hemoglobin.

Hb Setif (or HBA2: c.283G4T) is one of these variants with a mutation at codon 94 of of the a2-globin gene that is characterized History in clinically normal heterozygous individuals. We here...

Molecular and hematologic analysis of hemoglobin Q-Iran and hemoglobin Setif in Iranian families.

2015年11月16日 · Hb Setif (or HBA2: c.283G>T) is one of these variants with a mutation at codon 94 of of the α2-globin gene that is characterized in clinically normal heterozygous individuals. We here report...

Quantity in heterozygotes 12-15%; red cells with Hb Setif "sickle" by intracellular crystallization of insoluble Hb