Influenza A virus subtype H7N9 (A/H7N9) is a subtype of the influenza A virus, which causes influenza (flu), predominantly in birds. It is enzootic (maintained in the population) in many bird populations. [1]

2013年12月10日 · Here we assess the impact of the NA-R292K substitution on antiviral sensitivity and viral replication, pathogenicity and transmissibility of H7N9 viruses. Our data indicate that an H7N9...

2013年5月16日 · A confirmed case of human infection with avian-origin influenza A (H7N9) virus was defined as evidence of pneumonia with H7N9 viral RNA or isolation of H7N9 virus from respiratory specimens...

Importantly, neuraminidase (NA) inhibitor (NAI) resistance (R292K in NA) and mammalian adaptation (e.g., E627K and A588V in PB2) mutations were found in a few non-human-derived HP-H7N9 strains. In summary, the enhanced prevalence and diverse genetic characteristics that occurred with mammalian-adapted and NAI-resistant mutations may have ...

2019年12月11日 · H7N9 avian influenza virus causes severe infections and might have the potential to trigger a major pandemic. Molecular determinants of human humoral immune response to N9 neuraminidase (NA) proteins, which exhibit unusual features compared with seasonal influenza virus NA proteins, are ill-defined.

2017年9月1日 · In H7N9 AIV patients treated with NA inhibitors (NAIs), resistant mutations have been detected, such as an R292K substitution in NA that confers resistance to oseltamivir 68, 69, 70, 71, 72, 73. Based on the available gene sequences of human H7N9 isolates, we found that 24 out of 606 viruses contain the R292K substitution (including some ...

2025年1月9日 · Here, we isolate and purify a hemagglutinin (HA)-specific nanobody that recognizes an H7 subtype of influenza A virus. The nanobody, named E10, exhibits broad-spectrum binding, cross-group...

2023年6月8日 · The novel influenza A(H7N9) virus is the first low- pathogenic avian influenza virus (LPAI) documented to have caused severe human disease and which evolved in a highly pathogenic form (https://pubmed.ncbi.nlm.nih.gov/30269969/). An avian influenza strain is called 'low-pathogenic' or ‘highly pathogenic’ based on its capacity to cause ...

2024年5月27日 · The most potent mAb H7.167 from a study of EBV transformed B cells from five representative H7N9 experimental vaccinees neutralized H7N9 and protected mice against a sub-lethal challenge of...

Phylogenetic trees of HA and NA fragments showed that the novel H7N9 strains form a well-supported clade (with a bootstrap value of 100%) and the sequence from this patient clusters closely with those from the patients in Shanghai, Auhui and Zhejiang, as well as those from the poultry (including chickens and pigeon) from the local area and ...