常见组蛋白修饰 - 简书
2020年10月6日 · H3K27me3是组蛋白H3上的27位赖氨酸发生三甲基化，这种三甲基化通过形成异染色质区域 下调附近基因。 在赖氨酸27上放置抑制标记需要通过转录因子募集染色质调节子 …
Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active …
2014年1月9日 · H3K27me1 accumulates within transcribed genes, promotes transcription, and is regulated by Setd2-dependent H3K36me3 deposition. Contrarily, H3K27me2 is present on …
H3.1K27me1 loss confers - Nature
2023年11月18日 · These results suggested that H3K27me1 might act as a repressive marker to regulate the replication of rDNA, and recruitment of HRR factors onto rDNA.
H3.1K27me1 maintains transcriptional silencing and
2021年1月13日 · In plants, one of the most well-studied genome maintenance pathways involves the histone post-translational modification (PTM) H3K27me1. The loss of H3K27me1 results in …
Diurnal control of H3K27me1 deposition shapes expression of a …
2024年11月1日 · Here we have studied the diurnal regulation of the repressive mark H3K27me1 and its role in the control of DDR gene expression as a novel regulatory layer dependent on its …
Accurate H3K27 methylation can be established de novo by SUZ12 ... - Nature
2018年2月26日 · H3K27me1 and H3K27me3 each account for 10–15% of histone H3 methylation in mESCs, but, unlike H3K27me2, they associate with distinct genomic features. H3K27me1 is …
EZH1 Mediates Methylation on Histone H3 Lysine 27 and ... - Cell …
2008年11月21日 · Trimethylation on H3K27 (H3K27me3) mediated by Polycomb repressive complex 2 (PRC2) has been linked to embryonic stem cell (ESC) identity and pluripotency. …
ATXR5 and ATXR6 are H3K27 monomethyltransferases required …
Here we show that the divergent SET-domain proteins ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) and ATXR6 have H3K27 monomethyltransferase activity, and atxr5 …
Dissecting the role of H3K27 acetylation and methylation in …
2019年4月11日 · PRC2 methylates lysine 27 on histone H3 (H3K27me), while PRC1 mono-ubiquitinates histone H2A at lysine 119 (H2Aub1). Here we present engineered mouse …
Epigenetics Chromatin：H3K27me1对破骨细胞生成过程中MMP-9 …
通过识别h3k27me1标记，mmp-9在编码破骨细胞分化因子的基因上定位并产生h3nt蛋白水解。 通过使用RNAi和小分子抑制剂方法，我们还证实G9a是催化H3K27me1的MMP-9依赖性H3NT蛋 …