H3K9me3 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the tri-methylation at the 9th lysine residue of the histone H3 protein and is often associated with heterochromatin.

Nov 9, 2023 · H3K9me3作为真核细胞内最重要的抑制性组蛋白修饰，对于抑制基因组内广泛存在的重复序列和维持基因组稳定性是至关重要的。 然而，在DNA复制时其在新合成DNA链的分配模式及遗传机制则尚不清楚。

Abstract: H3K9me3 heterochromatin, established by lysine methyltransferases (KMTs) and compacted by heterochromatin protein 1 (HP1) isoforms, represses alternative lineage genes and DNA repeats. Our understanding of H3K9me3 heterochromatin stability is presently limited to individual domains and DNA repeats.

Nov 8, 2023 · Collectively, we describe a new H3K9me3-sensing and regulatory pathway that operates to epigenetically silence evolutionarily young ERVs and exert substantial effects on host genome integrity,...

May 13, 2021 · Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite repeats and genes,...

Oct 31, 2024 · H3K9me3 heterochromatin, established by lysine methyltransferases (KMTs) and compacted by heterochromatin protein 1 (HP1) isoforms, represses alternative lineage genes and...

H3K9me3 is a dynamic covalent post-translational histone modification which is known to be pathologically deregulated in a number of diseases including haematopoietic malignancies. It is tightly controlled by a number of enzymes which place, maintain and remove H3K9me3 such as the KDM4 family which are rapidly emerging as factors which ...

Here, we profiled genome-wide H3K9me3 in human oocytes and early embryos and discovered stage-specific H3K9me3 deposition on long terminal repeats (LTRs) at the 8-cell and blastocyst stages. We found that 8-cell specific H3K9me3 was temporarily established in enhancer-like regions, while blastocyst-specific H3K9me3 was more stable.

Histone 3 lysine 9 trimethylation (H3K9me3) is a conserved histone modification that is best known for its role in constitutive heterochromatin formation and the repression of repetitive DNA elements.

Apr 1, 2019 · The ability of H3K9me3 to influence cell identity challenges the original concept of H3K9me3-marked heterochromatin as mainly a constitutive type of chromatin and provides a further level of understanding of how to modulate cell fate control.