H3K9ac is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the acetylation at the 9th lysine residue of the histone H3 protein. The H3K9 histone has two jobs. Genes get turned on if this mark is acetylated and silences them if methylated.

h3k9甲基化就是一种很重要的表观遗传现象。h3k9甲基化就是组蛋白3的第9位氨基酸赖氨酸的甲基化，当这种甲基化的组蛋白3增多的时候dna就会和组蛋白更紧密的结合在一起，同时它自己也超螺旋化----紧密的盘曲在一起。

2021年5月13日 · We examine the effects of H3K9-methylation-dependent gene repression in haematopoiesis, muscle differentiation and neurogenesis in mammals, and compare them with mechanistic insights obtained...

2021年11月4日 · In Caenorhabditis elegans, loss of H3K9me leads to a highly divergent upregulation of genes with tissue and developmental-stage specificity. During development H3K9me is lost from differentiated...

2023年9月12日 · Histone H3 lysine 9 (H3K9) methylation, as a hallmark of heterochromatin, has a central role in cell lineage and fate determination. Although evidence of a cooperation between H3K9 methylation writers and their readers has started to …

在转录激活 (h3k4、k36、k79) 和沉默 (h3k9、 k27、h4k20) 中都涉及到赖氨酸甲基化。 甲基化程度与不同的转录效应相关。 例如，在激活基因的主体上能观察到 H4K20 单甲基化 (H4K20me1)，而 H4K20 三甲基化 (H4K20me3) 则属于基因抑制和压缩的基因组区域。

2019年9月20日 · Histone 3 lysine 9 trimethylation (H3K9me3) is a conserved histone modification that is best known for its role in constitutive heterochromatin formation and the repression of repetitive DNA elements.

2021年5月13日 · Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms. In mammalian cells,...

2024年6月26日 · Histone H3 lysine-9 methylation (H3K9me) is a hallmark of the condensed and transcriptionally silent heterochromatin. It remains unclear how H3K9me controls transcription silencing and how cells delimit H3K9me domains to avoid silencing essential genes.

2021年7月16日 · Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms. In mammalian cells, H3K9 methylation can be catalyzed by at least six distinct SET domain enzymes: Suv39h1/Suv39h2, Eset1/Eset2 and G9a/Glp.