Mar 1, 2023 · Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites and has been proposed to regulate transcription initiation1,2. However, redundant functions of the ...

Jun 15, 2016 · Although H3K4me3 modifications occur consistently at transcription start sites, the breadth of the H3K4me3 domain is a highly dynamic feature. Notably, the broad H3K4me3 domain (wider than 5 kb ...

Jun 21, 2024 · Epigenetic modifications, including posttranslational modifications of histones, are closely linked to transcriptional regulation. Trimethylated H3 lysine 4 (H3K4me3) is one of the most studied histone modifications owing to its enrichment at the start sites of transcription and its association with gene expression and processes determining cell fate, development, and …

Jan 7, 2019 · H3K4me3 broad domains are reviewed briefly below to document what is known about this new and interesting epigenetic signature. Fig. 4. Intensity and breadth are distinct attributes of H3K4me3 peaks. H3K4me3 peaks are typically found upstream and downstream of the TSSs of active genes (TTS = transcription termination site). Peak intensity ...

Jun 21, 2024 · Epigenetic modifications, including posttranslational modifications of histones, are closely linked to transcriptional regulation. Trimethylated H3 lysine 4 (H3K4me3) is one of the most studied histone modifications owing to its enrichment at the start sites of transcription and its association with gene expression and processes determining cell fate, development, and …

Mar 4, 2025 · Epigenetic programming governs cell fate determination during development through intricately controlling sequential gene activation and repression. Although H3K4me3 is widely recognized as a ...

H3K4me3 profiles were obtained in 13 benchmark cell lines.Random sampling of 5% sets of H3K4me3 domains from 0%–95% of the H3K4me3 breadth distribution matched to the corresponding top 5% broadest domains from each cell line was performed 100 times, and co-occurrence of each H3K4me3 domain with other features (e.g., transcription factor ...

We review evidence from histone residue mutation, histone modifier manipulation, and epigenetic editing, focusing on the relative roles of H3K4me1 and H3K4me3. We conclude that H3K4me1 and H3K4me3 may have convergent functions in establishing open chromatin and promoting transcriptional activation during cell differentiation.

Mar 22, 2025 · Mammalian genomes undergo pervasive transcription in both genic and intergenic regions. Tri-methylation of histone H3 lysine 4 (H3K4me3) is a deeply conserved and functionally important histone modification enriched at transcriptionally active promoters, where it facilitates RNA polymerase activity. H3K4me3 is also commonly found in intergenic regions, where its …

H3K4me3 formation is regulated by many methylated catalyzes. Intrinsic and external factors can stimulate the expression of these modifiers, like their epistatic transcriptional factors and other unknown factors. In this case, the fluctuation of H3K4me3 distribution is the consequence. The defective upstream mechanisms of histone modification ...