2023年9月8日 · H3K27ac是组蛋白H3上的第27位赖氨酸残基发生乙酰化，与较高的转录激活有关，在TSS（转录起始位点）的近端远端都有发现。 对于癌症来讲，不受控的细胞增殖涉及大 …

H3K27me3 is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the tri- methylation of lysine 27 on histone H3 protein. This tri-methylation is …

H3K27 is the 27th amino acid in Histone H3, which as a lysine is written "K" in single-letter amino acid notation. It is subject to posttranslational modification with epigenetic effects: H3K27ac, …

Methylation of lysine 27 on histone 3 (H3K27me), a modification usually associated with gene repression, has established roles in regulating the expression of genes involved in lineage …

Methylation of histone H3 on lysine 27 (H3K27) is frequently found in the heterochromatin and conceives a repressive marker that is linked with gene silencing. The identification of enzymes …

Properly timed addition and removal of histone 3 lysine 27 tri-methylation (H3K27me3) is critical for enabling proper differentiation throughout all stages of development and, likewise, can …

2019年4月11日 · PRC2 methylates lysine 27 on histone H3 (H3K27me), while PRC1 mono-ubiquitinates histone H2A at lysine 119 (H2Aub1). Here we present engineered mouse …

2024年1月4日 · We describe the role of H3 histone 27 lysine trimethylation as an important epigenetic regulatory mechanism in the development of various cancers via effects on …

Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of lysine 27 on histone H3 (H3K27me). This histone modification is a feature of facultative …

h3k27被认为是染色质相关酶的关键底物。 正常发育所需的PRC2负责甲基化H3K27，但它可以甲基化其他蛋白质 【4,7】 。 CBP和EP300乙酰化H3K27，并具有许多其他组蛋白乙酰化底物 …