2023年2月13日 · In the first step of the reaction mechanism of all PRXs and CysGPXs, and GPX7, H 2 O 2 reacts with the peroxidatic cysteine (C P) to form a sulfenic acid (SOH) intermediate. Whilst in SecGPXs, a...

H2O2依赖性氧化的最敏感靶标是过氧化物酶（PRX）或 谷胱甘肽过氧化物酶 （GPX）家族的 硫醇过氧化物酶。 这些硫醇过氧化物酶的去质子化过氧化硫醇在细胞内所有蛋白质中对H2O2的亲和力最高。 这一奇特的特性使这些过氧化物酶成为主要H2O2传感蛋白的理想候选。

In the present study, we cloned the GPx gene and created GPx-silenced strains by the down-regulation of GPx gene expression using RNA interference. The results indicated an essential role for GPx in controlling the intracellular H2O2 content, hyphal branching, antioxidant stress tolerance, cytosolic Ca(2+) content and ganoderic acid biosynthesis.

2022年7月1日 · GPxs catalyze the reduction of hydroperoxides by different thiols. Hydroperoxide reduction is achieved by oxidation of a selenocysteine or cysteine. The efficiency is due to a concerted dual attack of selenolate (thiolate) and a proton. The discoveries leading to our present understanding of the glutathione peroxidases (GPxs) are recalled.

2015年9月1日 · Glutathione peroxidase (GPx), peroxiredoxin (Prx) and catalase are the major antioxidants at the cellular level and protect cell compartments against hydrogen peroxide (H 2 O 2). In...

Hydrogen peroxide (H2O2) and hydroperoxides (ROOH) are degraded by GSH peroxidase (GPx) to water and alcohols, respectively. GSH disulfide (GSSG), the oxidized form of GSH, is reduced back to...

Using genetically altered human glioma cells in in vitro cell culture and in an in vivo tumour model, they inferred that the rate of removal of H2O2 was a direct function of GPx activity x GSH (effective GPx activity).

Although its concentration is generally not known, glutathione peroxidase-1 (GPx-1) is a key enzyme in the removal of hydrogen peroxide (H 2 O 2) in biological systems. Extrapolating from kinetic results obtained in vitro using dilute, homogenous buffered solutions, it is generally accepted that the rate of elimination of H 2 O 2 in vivo by GPx ...

GPx是一种哺乳动物中的抗氧化酶，其主要作用是在谷胱甘肽或其他硫醇的共同作用下，清除活性氧族（Reactive Oxygen Species，ROS），具有清除过氧化氢、脂及磷脂自由基，保护膜结构，保护脂蛋白、DNA等生物大分子，参与炎症调节等作用。

2023年9月1日 · Our findings indicate that GPx1 is a dominant enzyme involved in the hypoxic tumor-mediated catabolism of H 2 O 2 in glioblastoma. Tumor hypoxia leads to upregulation of GPx1, preventing H 2 O 2 overload and apoptosis in glioblastoma cells and xenografts via a HIF1-α–dependent pathway.