2023年8月14日 · Previous studies show that both EZH2, an epigenetic regulator that catalyzes lysine 27 trimethylation on histone 3 (H3K27me3), and long non-coding RNA H19 are highly correlated with...

2023年8月14日 · Integrated analysis of RNA-sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) further revealed that H19 regulated the reprogramming of EZH2-mediated H3K27me3 profiles, which epigenetically promoted several pathways favoring HSCs activation and proliferation, …

Previous studies show that both EZH2, an epigenetic regulator that catalyzes lysine 27 trimethylation on histone 3 (H3K27me3), and long non-coding RNA H19 are highly correlated with brogenesis....

RNA 测序 （RNA-seq） 和染色质免疫沉淀测序 （ChIP-seq） 的综合分析进一步揭示，H19 调节 EZH2 介导的 H3K27me3 谱的重编程，这在表观遗传上促进了有利于 HSCs 活化和增殖的几种途径，包括上皮-间充质转化和 Wnt/β-catenin 信号传导。

体内外结果表明，h19过表达促进hscs的活化与纤维化进展，而3-dznep（ezh2抑制剂）可显著改善其疾病的进一步发展。 RNA pulldown和RIP技术证明H19可有效结合EZH2。

2024年12月1日 · EZH2 functions as a modulator of the trimethylation of lysine 27 on histone 3, specifically targeting H3K27me3, and highly expressed H19 interacts with EZH2 to enhance fibrosis by altering the epigenetic control of HSCs activation mediated by EZH2 (Li et al., 2023). H19 directly binds to the 3′UTR and interacts with miR-29b, leading to an ...

Previous studies show that both EZH2, an epigenetic regulator that catalyzes lysine 27 trimethylation on histone 3 (H3K27me3), and long non-coding RNA H19 are highly correlated with fibrogenesis. In the current study, we investigated the underlying mechanisms.

2016年5月13日 · In this study, we evaluated the effects of H19 and EZH2 on the invasive ability of NPC cells and explored their potential relationship in NPC. The results showed that both H19 and EZH2 promote invasion by NPC cells. H19 enhanced EZH2 expression by interacting with miR-630 and inhibiting its activity.

2016年4月6日 · Rather than direct interaction, H19 regulated EZH2 expression by suppressing the activity of miR-630, which is a repressor of EZH2 and interacts with H19 in a sequence-specific manner. Furthermore, H19 inhibited E-cadherin expression and promoted cell invasion of NPC cells via the miR-630/EZH2 pathway.

In this study, we found a negative correlation between H19 lncRNA and EZH2 expression levels with good values of Spearman correlation coefficient in neoplastic tissues samples, and even better in EBV-positive neoplastic samples, in both cases with statistical significance.