Histone H1 - Wikipedia
Histone H1 is one of the five main histone protein families which are components of chromatin in eukaryotic cells. Though highly conserved, it is nevertheless the most variable histone in sequence across species.
The H1 linker histones: multifunctional proteins beyond the …
The linker histone H1 family members are a key component of chromatin and bind to the nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both nucleosome structure and higher-order chromatin architecture. In general, H1 ...
H1 histones: current perspectives and challenges - PMC
We review recent progress in understanding the structure, genetics and posttranslational modifications of linker histones, with an emphasis on the dynamic interactions of these proteins with DNA and transcriptional regulators.
Emerging roles of linker histones in regulating chromatin ... - Nature
2017年10月11日 · Studies using X-ray crystallography, NMR and cryo-electron microscopy (cryo-EM) reveal that linker histones (H1) bind to nucleosomes via electrostatic interactions and that this binding can occur...
H1 histones control the epigenetic landscape by local chromatin ...
2020年12月9日 · Here we show that the local density of H1 controls the balance of repressive and active chromatin domains by promoting genomic compaction. We generated a conditional triple-H1-knockout...
Role of H1 Linker Histones in Mammalian Development and Stem …
H1 linker histones are key chromatin architectural proteins facilitating the formation of higher order chromatin structures. The H1 family constitutes the most heterogeneous group of histone proteins, with eleven non-allelic H1 variants in mammals.
Linker histone H1 and protein-protein interactions - PMC
Linker histones H1 are ubiquitous chromatin proteins that play important roles in chromatin compaction, transcription regulation, nucleosome spacing and chromosome spacing. H1 function in DNA and chromatin structure stabilization is well studied and established.
Full article: Histone H1, the Forgotten Histone - Taylor & Francis …
2019年2月22日 · The described H1-protein interaction partners encompass pre-mRNA splicing factors, histone chaperones, components of the transcription machinery, DNA-damage response factors and even components of the translation machinery, which demonstrates that H1 is involved in diverse processes [Citation 19].
Histone H1 - an overview | ScienceDirect Topics
Histone H1 is the fifth nucleosome-binding protein, following H2A, H2B, H3, and H4, and is positioned in doublets around a segment of which two turns of DNA are attached. A recent study also suggested the role of H1 in the response to DNA double-strand breaks (DSBs) through the interaction of ubiquitin-mediated proteolysis ( Thorslund et al ...
The roles of histone variants in fine-tuning chromatin ... - Nature
2020年7月14日 · Histone variants are characterized by a distinct protein sequence and a selection of designated chaperone systems and chromatin remodelling complexes that regulate their localization in the...