2025年3月30日 · GZMB (Granzyme B) is a Protein Coding gene. Diseases associated with GZMB include Stevens-Johnson Syndrome and Peripheral T-Cell Lymphoma. Among its related pathways are Signaling by ALK fusions and activated point mutants and Programmed Cell Death.

2021年1月12日 · GzmB mediates loss of hemidesmosomal proteins, type XVII collagen (COL17) and α6 integrin, in an EBA murine model. We next aimed to elucidate the mechanisms underlying GzmB-mediated PD...

2024年8月23日 · Widely recognized as intracellular mediators of cell death, granzymes, particularly granzyme B (GzmB), also accumulate in the extracellular milieu of tissues with age, contributing to chronic tissue injury, inflammation, and impaired healing.

2025年2月8日 · Title: A robust gene prognostic index composed of GZMB, IRF1, and TP63 can stratify the risk of two metastatic urothelial carcinoma cohorts based on immune checkpoint blockade therapy. Granzyme B Contributes to Choroidal Neovascularization and Age-Related Macular Degeneration Through Proteolysis of Thrombospondin-1.

2014年12月18日 · Granzyme B (GzmB) is a protease with a well-characterized intracellular role in targeted destruction of compromised cells by cytotoxic lymphocytes. However, GzmB also cleaves extracellular matrix components, suggesting that it influences the interplay between cytotoxic lymphocytes and their environm …

GZMs are a family of serine proteases that were originally identified in the cytotoxic granules of cytotoxic T and NK cells. The most-abundant and best-characterized members, GZMA and GZMB, have been found in several immune and, more recently, non-immune cell types.

Human and murine Granzymes play important roles in immune responses, crucial for eliminating aberrant cells. GzmB, a serine protease initially identified in the granules of cytotoxic lymphocytes, aids in eliminating infected or transformed cells via inducing apoptotic cell death (1).

2022年11月9日 · Our study support the involvement of GzmB-expressing CD8+ T cells in the inflammatory response in patients with NMOSD and provide a potential biomarker for disease immunotherapy effectiveness and disability progression.

2013年8月2日 · Granzyme B (GzmB) is a serine protease expressed during chronic inflammation that, in conjunction with perforin, has a well-established role in initiating apoptotic cell death. GzmB is also...

Human granzyme B binds Plasmodium falciparum Hsp70-x and mediates antiplasmodial activity in vitro. A robust gene prognostic index composed of GZMB, IRF1, and TP63 can stratify the risk of two metastatic urothelial carcinoma cohorts based on immune checkpoint blockade therapy.