2022年5月1日 · Gonadal white adipose tissue (gWAT) can regulate gametogenesis via modulation of neuroendocrine signaling. However, the effect of gWAT on the local microenvironment of the gonad was largely unknown.

Gonadal white adipose tissue (gWAT) can regulate game-togenesis via modulation of neuroendocrine signaling. How-ever, the effect of gWAT on the local microenvironment of the gonad was largely unknown. Herein, we ruled out that gWAT had a neuroendocrine effect on gonad function through a unilateral lipectomy strategy, in which cutting off epididymal

为了在更大的数据集中检验SAT亚型比例是否受BMI的影响，本研究对43名女性皮下脂肪细胞的bluk RNA-seq数据分析，发现hAd4 和 hAd7 亚群与 BMI 呈负相关，而hAd5 比例与 BMI 呈正相关，与免疫组化结果一致（图3d）。 为研究单个脂肪细胞亚群是否具有特定功能，作者分析了参与脂肪细胞代谢的基因，并通过聚类分析，确定了亚群 hAd3-hAd7 。 hAd3 与“甘油三酯生物合成”相关，包括DGAT2、SREBF1和PNPLA3的更高表达。 hAd4表达最高量的几种脂肪酸去饱和酶， …

To examine the cellular altas and developmental aspects of male gWAT, we performed Single-cell RNA-seqs on different developing stage of gWAT (P3,P7 and 5-week). To examine the mesothelial origin hypothesis of gWAT, we also performed Single-cell RNA-seq on P7 gWAT associated mesothelial cells.

2021年10月29日 · Global deficiency of Spry1 in mice results in disproportionate postnatal growth of gonadal WAT (gWAT), while iWAT and BAT were similar in size between Spry1 KO and WT mice. Spry1 deficiency increased the number of PDGFRa+ stromal vascular fraction (SVF) cells in gWAT and showed increased proliferation and fibrosis.

2016年1月1日 · FACS analysis of the frequency (A), lipid staining intensity (mean fluorescence intensity: MFI) (B) and complexity (sidescatter area: SSA) (C) of macrophages in the gWAT of controls and mice treated with CL316,243 (CL) for up to 7 d.

Gonadal white adipose tissue (gWAT) can regulate gametogenesis via modulation of neuroendocrine signaling. However, the effect of gWAT on the local microenvironment of the gonad was largely unknown.

2022年5月20日 · We generated mouse models with specific deletion of the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) from adipose tissue. Deletion of Pgam1 from both BAT and WAT promoted whitening of BAT with beiging of visceral WAT, whereas deletion of Pgam1 from BAT alone led to whitening of BAT without beiging of WAT.

2017年12月7日 · We conducted a time course analysis of global transcriptome changes in gonadal white adipose tissue (gWAT) during the weight fluctuation. Co-expression network analysis was used to identify...

2021年12月1日 · Accumulating evidence from genetic fate mapping studies suggests that in animal models receiving a high-fat diet (HFD), only adipocyte progenitors (APs) in gonadal white adipose tissue (gWAT) have proliferative potential.