Potential of TCR sequencing in graft-versus-host disease
2022年12月7日 · Monitoring the frequency and specificities of specific TCR clonotypes longitudinally in different conditions and specimens (peripheral blood, GvHD-affected tissue …
TCR Repertoires in Graft-Versus-Host-Disease (GVHD)-Target …
2020年11月5日 · Prior studies of T cell receptor (TCR) sequencing in diagnostic biopsies and blood have identified dominant T cell clones in GVHD-affected tissues that were not abundant …
Donor regulatory T cells rapidly adapt to recipient tissues to …
2024年4月15日 · Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a curative treatment option for many patients with hematologic malignancies but bears the risk of inducing...
怎么又双叒叕GvHD了？--GvHD模型的建立与应用 - 知乎
异基因造血干细胞移植（allogeneic hematopoietic stem cell transplantation，allo-HSCT）是治疗白血病、淋巴瘤以及其他恶性血液病和免疫学疾病的有效措施，然而移植物抗宿主病（graft …
Science新发现！TCR测序提供GVHD病理机制新见解 - Pharmcube
2024年2月23日 · 在30-50%的同种异体造血细胞移植（allo-HCT）受者中，异种反应性T细胞识别受体抗原触发急性移植物抗宿主病（GVHD），主要攻击皮肤、胃肠道和肝脏。 发生免疫激活 …
One Is Better than Two: TCR Pairing and GVHD - Science
2013年6月5日 · Functional donor T cells that expressed dual T cell receptors were found at an increased frequency in patients who developed acute GVHD as compared with that in healthy …
TCR spectratyping revealed T lymphocytes associated with …
Among the 49 over-expanded clones identified, clonotype "TCR3-5" and "TCR18-5" were isolated from four patients with HLA-A2 allele and skin GVHD. Their frequencies correlated well with …
Multimodal immune cell phenotyping in GI biopsies reveals …
2023年7月18日 · Our evidence on TCR clonality, distribution, and longevity in GvHD-affected organs suggests that antigen specificity could play an important role in the setting of GI GvHD.
T cell receptor gene-modified allogeneic T cells with siRNA for ...
2023年9月7日 · In this study, we evaluated the anti-tumor efficacy and the potential to induce graft-versus-host disease (GVHD) in T cell receptor (TCR) gene-engineered allogeneic T cells …
understand the underlying mechanisms mediating GvHD. This review provides insights into current studies of the TCR repertoire in GvHD and potential future clinical implications of TCR...
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