Associated with GVHD is the well-recognized phenomenon of the graft-versus-leukemia (GVL) effect that results in reduced risk of disease relapse. GVL effects have been observed after treatment for a broad range of hematological malignancies.

Chronic graft versus host disease (cGvHD) is an immunologic phenomenon wherein alloreactive donor T cells aberrantly react against host tissues, leading to damaging inflammatory symptoms. Here, we discuss biological insights into GvL and cGvHD and strategies to balance the prevention of GvHD with maintenance of GvL in modern HSCT.

病（GVHD）和移植后肿瘤复发是影响患者存活 率的主要障碍[1]。移植物抗白血病效应 （GVL）是alloHSCT治愈血液系统恶性肿瘤的 主要机制。GVHD与GVL效应的机制目前尚 未完全明确，但两者均为由供者T细胞介导的 免疫反应。

2024年11月5日 · GvL effects have been closely linked to graft-versus-host disease (GVHD), and many studies have observed a significant association between GVHD occurrence and lower incidence of AML relapse after allo-HCT 1,2.

具中科博生研究表明，移植物抗宿五病(gvhd)是allo-hsct的主要合并症，发生基础在于供受者hla的差异，是由移植物中的抗原特异性淋巴细胞识别宿主组织抗原而发生的排斥反应。

2009年7月1日 · Routine methods to maximize the graft-versus-leukemia (GvL) activity of allogeneic hematopoietic stem cell transplantation (HSCT) without the detrimental effects of graft-versus-host disease (GvHD) are lacking. Depletion or inhibition of alloreactive T cells is partially effective in preventing GvHD, but usually leads to decreased GvL activity.

3 天之前 · In this study, we aimed to identify donor CD4 + and CD8 + T cell subsets that attenuate GVHD while promoting GVL for the development of optimal donor selection indicators and therapeutic targets ...

GVHD is a life-threatening complication that leads to dysfunction of multiple tissues and organs, including the gastrointestinal tract, liver, lungs and skin. On the other hand, transplanted donor T cells exert a potent anti-tumor effect, called graft-versus-tumor (GVT) or graft-versus-leukemia (GVL) effects, by recognizing recipient allo ...

2025年3月26日 · Graft-versus-host disease (GvHD) is a prevalent complication following allogeneic hematopoietic stem cell transplantation (HSCT) and is characterized by relatively high morbidity and mortality rates. GvHD can result in extensive systemic damage in patients following allogeneic HSCT (allo-HSCT), with the skin, gastrointestinal tract, and liver frequently being the primary target organs affected ...

从t细胞、nk细胞分子识别角度探讨gvhd及gvl效应发病及调控机制，以期为防治gvhd及提高gvl效应，并人为地将二者区分开来提供理论基础。 引用本文: 段连宁, 郭坤元, 王学文.