2024年6月7日 · Graft-versus-host disease (GVHD) is a severe complication that can occur following hematopoietic stem cell transplantation. This condition arises when immunocompetent T lymphocytes from the donor graft recognize the recipient's tissues as foreign due to histocompatibility differences and initiate an immune response against them.

Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. GvHD is commonly associated with bone marrow transplants and stem cell transplants. White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). The ...

2023年6月8日 · Acute GVHD is caused by the recognition and the destruction of the recipient tissues and organs by the donor immune effector cells. This condition usually occurs within the first 3 months...

移植物抗宿主病（gvhd）是由于移植后异体供者移植物中的t淋巴细胞，经受者发动的一系列“细胞因子风暴”刺激，大大增强了其对受者抗原的免疫反应，以受者靶细胞为目标发动细胞毒攻击，其中皮肤、肝及肠道是主要的靶目标。

2024年8月28日 · 急性GVHD是由供体免疫效应细胞对受体组织和器官的识别和破坏所引起，通常发生于alloHCT后的前3个月内，但也可能迟发。 急性GVHD的靶器官包括皮肤、消化道和肝脏，诊断以临床检查为主，辅助检查排除鉴别诊断。

移植物抗宿主病（GVHD）是造血干细胞移植（HSCT）后在患者体内重建的供者来源的免疫细胞攻击受者脏器造成的组织损伤，是异基因HSCT（allo-HSCT）特有的合并症，重症GVHD是移植失败的重要原因之一 [1] – [5]。 GVHD分为急性GVHD（aGVHD）和慢性GVHD（cGVHD）。 按照最新修订的NIH标准 [2]，aGVHD和cGVHD的划分依据为发生时间和临床表现。 广义aGVHD包括经典的aGVHD和持续、复发或晚发的aGVHD。 经典aGVHD指发生在移植后100 d内或供者淋 …

Graft-versus-host disease (GVHD) is a major factor contributing to mortality and morbidity after allogeneic haematopoietic stem-cell transplantation (HSCT). In the last 3 years, there has been regulatory approval of new drugs and considerable change in clinical approaches to prophylaxis and manageme …

2024年4月11日 · The pathophysiology of GvHD is described as a 3 step process starting with initial tissue damage by conditioning followed by host antigen presenting cell activation by damage and pathogen associated molecular patterns and finally resulting in activation of alloreactive T cells and proinflmmatory cytokines inducing target cell apoptosis.

2024年11月9日 · Graft-versus-host disease (GVHD) is a serious complication after allogeneic HCT. Recently, several pivotal studies have been conducted demonstrating significant improvements in the management of GVHD. Here, we review important trials pertaining to GVHD prevention, acute GVHD treatment, and treatment of steroid refractory acute and chronic GVHD.

Ⅰ级轻度GVHD，Ⅱ级中度GVHD，Ⅲ~Ⅳ级为重度GVHD，与死亡率显著相关。 相关解释: 急性GVHD的Glucksberg分级系统和IBMTR分级系统在评估预后方面仍有各自的优点。 参考来源: 王吉耀主编. 《内科学》（八年制）[M]. 人民卫生出版社.2005年.