In the gut, emerging evidence suggests that the immune dysregulation observed in acute GVHD leads to further perturbation of the intestinal epithelium, specifically intestinal stem cells, Paneth cells and goblet cells 13.

2016年3月24日 · Near certainty of GVHD diagnosis, a prerequisite for starting treatment that carries risk, can be achieved by combining a high pretest likelihood of GVHD with negative evidence of infection; consistent findings on physical examination, gut imaging, and endoscopic examination of gut mucosa; and typical histologic changes in intestinal crypts and ...

2017年12月7日 · A frequent complication of HSCT is acute graft-versus-host disease (GVHD), a condition in which immune cells from the donor attack healthy recipient tissues. The gastrointestinal system is among the most common sites affected by acute GVHD, and severe manifestations of acute GVHD of the gut portends a poor prognosis in patients after HSCT.

2023年6月8日 · Acute graft-versus-host disease (GVHD) is a common immune complication that can occur after allogeneic haematopoietic cell transplantation (alloHCT). Acute...

2025年1月3日 · MHC class II molecules on enterocytes have the ability to expose recipient T cells to donor-derived antigens, triggering an immunological response that results in GVHD. The gut microbiota has been found to affect the expression of MHC class II on enterocytes.

2025年3月1日 · Complications from graft-versus-host disease (GVHD) are a major source of morbidity and death, recently linked to gut dysbiosis in the hematopoietic stem cell transplantation (HSCT) population. But so far, no comprehensive study has been conducted to investigate this relationship in the children population.

Graft-versus-host disease (GVHD) of the gut is when transplanted cells attack the gut. This happens after a transplant. It can lead to very bad gut problems like inflammation and damage.

2021年10月27日 · In this review, we discuss the alterations and roles of the intestinal microbiota and its metabolites in acute GVHD, as well as interventions targeting microbiota for the prevention and treatment of acute GVHD.

2024年7月8日 · Symptoms and effects on your gut: Sickness, diarrhoea, indigestion, cramping feelings, and a lack of appetite; Could affect your mouth, oesophagus (food pipe), stomach and bowel. Acute gut GvHD usually affects the bowel. Treatments for gut GvHD: Drinking lots of fluids to avoid dehydration; Anti-diarrhoea medication in more severe cases

2019年5月1日 · Graft-versus-host disease (GvHD) is a common complication of hematopoietic cell transplantation that negatively impacts quality of life in recipients and can be fatal. Animal experiments and human studies provide compelling evidence that the gut microbiota is associated with risk of GvHD, but the na …