Full-length GSDME mediates pyroptosis independent from …
Jul 12, 2024 · We here discovered a form of pyroptosis mediated by full-length (FL) GSDME without proteolytic cleavage. Intense ultraviolet-C irradiation-triggered DNA damage activates …
Gasdermin E suppresses tumour growth by activating anti-tumour ... - Nature
Mar 11, 2020 · GSDME expression enhances the phagocytosis of tumour cells by tumour-associated macrophages, as well as the number and functions of tumour-infiltrating natural …
GSDME-mediated pyroptosis promotes the progression and
Feb 18, 2023 · GSDME expression is upregulated in atherosclerotic lesions, and GSDME deficiency suppresses pyroptosis-related inflammation and decreases the development of …
The multifaceted roles of GSDME-mediated pyroptosis in cancer ...
Gasdermin E (GSDME), a crucial component of the gasdermin (GSDM) family proteins, has the ability to convert caspase-3-mediated apoptosis to pyroptosis of cancer cells and activate anti …
GSDME and its role in cancer: From behind the scenes to the ... - PubMed
Jun 15, 2021 · Our review only focuses on GSDME and summarizes the current knowledge and most recent advances on GSDME's role in cancer formation, its potential as a biomarker in …
Gasdermin E suppresses tumour growth by activating anti-tumour ... - PubMed
Mar 20, 2020 · GSDME expression is suppressed in many cancers, and reduced GSDME levels are associated with decreased survival as a result of breast cancer 2,6, suggesting that …
GSDME-mediated pyroptosis contributes to chemotherapy …
Dec 19, 2024 · Herein, using human platelets and platelets from mice lacking gasdermin E (GSDME), we show that GSDME is functionally expressed in anucleate platelets, and that …
Gasdermin E: A Prospective Target for Therapy of Diseases
In this review, we emphasize the PCD mediated by GSDME, summarize the key roles of GSDME in both cancer and non-cancer diseases, and describe the potential therapeutic approaches …
GSDME : A Potential Ally in Cancer Detection and Treatment
Jan 6, 2021 · Gasdermin E (GSDME) is an executioner of caspase-3 mediated regulated pyroptosis, and as such plays an important role in several cancers. Recent findings highlighted …
The caspase-3/GSDME signal pathway as a switch between
Oct 28, 2020 · GSDME-mediated pyroptosis is correlated with the side effects of chemotherapy and anti-tumor immunity. This article mainly reviews the caspase-3/GSDME signal pathway as …