Mar 30, 2025 · GSDMB (Gasdermin B) is a Protein Coding gene. Diseases associated with GSDMB include Childhood-Onset Asthma and Oral Squamous Cell Carcinoma. An important …

Mar 29, 2023 · The cryo-EM structure of the GSDMB pore reveals mechanisms by which GSDMB pore-forming activity is regulated by pathogenic bacteria and mRNA splicing.

Mar 11, 2023 · Gasdermin (GSDM)-mediated pyroptosis is functionally involved in multiple diseases, but Gasdermin-B (GSDMB) exhibit cell death-dependent and independent activities …

Gasdermin B (GSDMB) belongs to the gasdermin (GSDM) family which may adopt different mechanisms of intramolecular domain interactions to modulate their lipid-binding and pore …

Jan 20, 2022 · Gasdermin B (GSDMB) is currently the least studied, and while its association with genetic susceptibility to chronic mucosal inflammatory disorders is well established, little is …

Dec 10, 2024 · Title: GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis. Structural and functional insights …

May 21, 2021 · Gasdermin B (GSDMB) belongs to a large family of pore-forming cytolysins that execute inflammatory cell death programs. While genetic studies have linked GSDMB …

Mar 29, 2023 · Here, we report the cryogenic electron microscopy structures of human GSDMB in complex with Shigella IpaH7.8 and the GSDMB pore. The structure of the GSDMB–IpaH7.8 …

Apr 16, 2020 · Zhou et al. show that granzyme A cleaves and activates gasdermin B (GSDMB), a central player in the highly inflammatory cell death process known as pyroptosis (see the …

Nov 23, 2023 · To exploit GSDMB antibiotic activity for gram-negative bacteria infection, it is essential first to characterize how GSDMB variants might differentially target internal and …