Grb2 is best known for its ability to link the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases, ERK1,2. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain .

Grb2蛋白 (growth factor receptor-bound protein 2)Grb2是生长因子受体结合蛋白2，又叫Ash蛋白，在人类中由Grb2基因编码。 该蛋白参与细胞内各种受体激活后的下游调节。 它能够直接与激活的 表皮生长因子受体 磷酸化的酪氨酸结合,参与EGF受体介导的信号转导,也能通过与Shc磷酸化的 酪氨酸 结合间接参与由 胰岛素受体介导的信号转导。 Grb2能够同时与Shc、Sos结合形成Shc-Grb2-Sos复合物,并将Sos激活，激活的Sos与质膜上的Ras蛋白结合，并将其激活,引起 信号级 …

2025年3月30日 · GRB2 (Growth Factor Receptor Bound Protein 2) is a Protein Coding gene. Diseases associated with GRB2 include Hepatitis C and Hepatitis E. Among its related pathways are Downstream signaling of activated FGFR2 and Prolactin Signaling. Gene Ontology (GO) annotations related to this gene include RNA binding and protein kinase binding.

2025年3月4日 · Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein involved in signal transduction and cell communication. Here we show that the expression of GRB2...

GRB2, or Growth Factor Receptor-Bound Protein 2, is a pivotal adaptor protein in intracellular signal transduction pathways, particularly within receptor tyrosine kinase (RTK) signaling cascades. Its crystal structure reveals a modular architecture ...

Growth-factor-receptor-binding protein 2 (GRB2) is a non-enzymatic adaptor protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene ...

6 天之前 · (B) The Grb2 YF allele was constructed by homologous recombination to integrate a loxP-flanked Neo cassette and a Y209F point mutation into the Grb2 locus. (C) PCR genotyping confirmed the presence of the Grb2 YF allele. (D) Grb2 mutant lens typical expression patterns of pERK, cell cycle markers p57 and Ki67 and differentiation markers Foxe3 ...

The growth factor receptor-bound protein-2 (GRB2) is essential for multiple cellular functions. Inhibition of GRB2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types. GRB2 is …

Growth Factor Receptor-bound protein 2 (Grb2) is a key molecule in intracellular signal transduction, linking activated cell surface receptors to downstream targets by binding to specific phosphotyrosine-containing and proline-rich sequence motifs.

2024年3月8日 · Growth factor receptor-bound protein 2 (GRB2) is a cytoplasmic adapter for tyrosine kinase signaling and a nuclear adapter for homology-directed-DNA...