Granzymes are a family of cytotoxic proteases that each act on unique sets of biological substrates within target cells, usually to induce cell death. Granzymes are differentially …

Granzymes belong to the serine-protease family, and five human members have been identified: granzyme A (GA), granzyme B (GB), granzyme H (GH), granzyme M (GM) and granzyme K …

2015年5月22日 · In this Review, we discuss the current understanding of the structural, cellular and clinical aspects of perforin and granzyme biology.

2001年2月12日 · Following receptor-mediated conjugate formation between a granzyme-containing cell and an infected or transformed target cell, granzymes enter the target cell via …

Granzyme A plays a role in CTL-induced apoptosis through the activation of a caspase-independent pathway. Granzyme A causes DNA nicking by activating DNAse NM23-HI (a …

2010年1月15日 · Although granzyme-mediated cell death has been intensively studied, recent work has also hinted at an alternative, proinflammatory role for these enzymes.

2 天之前 · Two recent studies by Donado et al. 10 and Lan et al. 11 report a previously unknown converging node between the granzyme family and the complement cascade, addressing the …

2025年2月6日 · Now, over 100 years after the complement system was first described, researchers at Mass General Brigham have discovered that a protein known as granzyme K …

2024年4月4日 · Here we review the current knowledge of granzyme functions, highlighting the processes through which granzymes contribute to cellular homeostasis as well as their …

2024年4月5日 · Outside the cell, granzyme activities mediate extracellular matrix alteration via the degradation of matrix proteins or surface receptors. In certain contexts, these processes are …