NR3C1 Gene - GeneCards | GCR Protein | GCR Antibody
2025年3月30日 · NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) is a Protein Coding gene. Diseases associated with NR3C1 include Glucocorticoid Resistance, Generalized and Primary Hyperaldosteronism. Among its related pathways are Gene expression (Transcription) and Infectious disease.
Expression of glucocorticoid receptor alpha- and beta-isoforms
Alternative splicing of the human glucocorticoid receptor (GR) primary transcript generates two protein isoforms: GR-alpha and GR-beta. We investigated the expression of both GR isoforms in healthy human cells and tissues. GR-alpha mRNA abundance (x10(6) cDNA copies/microg total RNA) was as follows: …
糖皮质激素受体 - 百度百科
植物转录因子研究中，常用的诱导表达系统是利用鼠的糖皮质激素受体（glucocorticoid receptor，GR）进行翻译后诱导。 其基本原理是：所研究的植物转录因子编码序列与GR的类固醇结合结构域编码序列融合。
Glucocorticoid receptor - Wikipedia
The glucocorticoid receptor (GR or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.
Glucocorticoid Receptor Alpha - an overview - ScienceDirect
Glucocorticoid receptor α is the active receptor, which binds to GC and transduces biological activity. Depending upon ligand availability, GR α shuttles between the cytoplasm and the nucleus.
德国研究团队研究发现糖皮质激素受体的抗炎功能需要DNA结合
GCs具有抗炎、抑制免疫、抗休克等作用，是临床上治疗诸多免疫性疾病、炎症性疾病和过敏性疾病的首选药物。 GR是由 NR3C1 基因编码的转录因子，主要存在于复杂的细胞质中，与 热休克蛋白 、亲免蛋白及其他防止其降解的因子共存，这些因子也可增强GR与其配体的亲和力，在与配体结合后，GR会产生形态变化。 在细胞核中，GR与DNA及其他蛋白质也存在交互作用。 一般来说，GR的抗炎作用是因为炎症基因的沉默，而其不良反应归因于代谢靶点的上调。 GR直接 …
Glucocorticoid receptors GRα and GRβ are expressed in
The actions of GCs are mediated by the glucocorticoid receptor (GR). Alternative splicing of GR mRNA gives rise to different isoforms, GRα and GRβ being the most important. GRβ antagonizes the activity of GRα and its up-regulation has been associated with glucocorticoid insensitivity in several non-cutaneous inflammatory diseases.
Anti-Glucocorticoid Receptor alpha抗体(ab3580) - Abcam中文官网
All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that alpha and beta forms of human GR are 777 and 742 amino acids long, respectively.
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Associations between promoter usage and alternative splicing of …
The glucocorticoid receptor (GR) is widely expressed in various tissues throughout the human body. At least three different 3'-splice variants of the GR have been reported: GR-alpha, which is functionally active; GR-beta, which is a dominant negative inhibitor of …
Immunocytochemical analysis of the glucocorticoid receptor alpha ...
1999年10月1日 · The alpha isoform of the glucocorticoid receptor (GRα) binds glucocorticoids and functions as a ligand-dependent transcription factor. Although GRα is expressed in almost all tissues and cells, its subcellular distribution is controversial.