2024年3月18日 · Tumour-derived lactate activates adipose GPR81, which in turn leads to cachexia. Targeting GPR81 and its downstream signalling pathway holds therapeutic potential …

GPR81 exerts its physiological functions by two different mechanisms, one by Gi-type G protein-dependent inhibition of adenylyl cyclase to depress lipolysis in adipocytes or to link brain …

Hydroxycarboxylic acid receptor 1 (HCA 1), formerly known as G protein-coupled receptor 81 (GPR81), is a protein that in humans is encoded by the HCAR1 gene. [5] [6] HCA 1, like the …

2024年3月18日，北京大学肖瑞平团队和胡新立团队联合在 Nature Metabolism 上在线发表了题为“Activation of GPR81 by lactate drives tumour-induced cachexia”的研究论文。 研究发现循环 …

2022年4月15日 · Here, we show that GPR81 regulates the malignant phenotype of breast cancer cell by reprogramming energy metabolism. We found that GPR81 is highly expressed in breast …

2024年3月18日，北京大学肖瑞平及胡新立共同通讯在Nature Metabolism在线发表题为“Activation of GPR81 by lactate drives tumour-induced cachexia”的研究论文，该研究发现在患有癌症恶病 …

GPR81 is a G-protein-coupled receptor for lactate, which is upregulated in breast cancer and plays an autocrine role to promote tumor growth by tumor cell-derived lactate. Here we asked …

2020年2月19日 · GPR81 is a G-protein-coupled receptor for lactate, which is upregulated in breast cancer and plays an autocrine role to promote tumor growth by tumor cell-derived...

在gpcr家族的大约800个成员中，gpr81，也称为羟基羧酸受体1（hcar1），是一种选择性乳酸敏感受体，已知在多种细胞类型中表达，包括脑细胞、脂肪细胞、各种癌细胞和视网膜等。

2014年9月15日 · GPR81 is a lactate receptor recently identified in adipose and muscle cells that has not been investigated in cancer. In the current study, we examined GPR81 expression …